hydrophobicity article 70 priority journal 58 nonhuman 48 unclassified drug 42 controlled study 38 Animals 24 Article 24 chemistry 24 molecular dynamics 20 human 18 metabolism 18 protein domain 18 Humans 16 Hydrophobic and Hydrophilic Interactions 16 Hydrophobicity 16 Models, Molecular 16 Protein Binding 16 chemical structure 16 hydrophilicity 16 Ligands 14 Molecular dynamics 14 conformational transition 14 enzyme active site 14 protein binding 14 protein conformation 14 surface property 14 water 14 Kinetics 12 Protein Structure, Secondary 12