CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases

CaV2.1 (P/Q type) Ca2+ channels have a fundamental role mediating fast transmitter release at central and peripheral synaptic terminals. Various neurological diseases have been attributed to genetic and autoimmune malfunctioning of P/Q channels, including ataxia, migraine and myasthenic syndromes. T...

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Detalles Bibliográficos
Autor principal: Uchitel, O.D.
Formato: CHAP
Materias:
Ataxia
CaV2.1 subunits
Channelopathy
Migraine
Myasthenic syndromes
P/Q type current
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97894007_v9789400763340_n_p263_Uchitel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:CaV2.1 (P/Q type) Ca2+ channels have a fundamental role mediating fast transmitter release at central and peripheral synaptic terminals. Various neurological diseases have been attributed to genetic and autoimmune malfunctioning of P/Q channels, including ataxia, migraine and myasthenic syndromes. This chapter focuses on recent advances on the understanding of the pathogenic mechanisms underlying these disorders. © Springer Science+Business Media Dordrecht 2013. All rights are reserved.

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