Novel therapeutic targets for arenavirus hemorrhagic fevers
Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several th...
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todo:paper_17460794_v6_n1_p27_Garca2023-10-03T16:32:02Z Novel therapeutic targets for arenavirus hemorrhagic fevers Garca, C.C. Seplveda, C.S. Damonte, E.B. antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_17460794_v6_n1_p27_Garca |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
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R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus |
spellingShingle |
antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus Garca, C.C. Seplveda, C.S. Damonte, E.B. Novel therapeutic targets for arenavirus hemorrhagic fevers |
topic_facet |
antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus |
description |
Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd. |
format |
JOUR |
author |
Garca, C.C. Seplveda, C.S. Damonte, E.B. |
author_facet |
Garca, C.C. Seplveda, C.S. Damonte, E.B. |
author_sort |
Garca, C.C. |
title |
Novel therapeutic targets for arenavirus hemorrhagic fevers |
title_short |
Novel therapeutic targets for arenavirus hemorrhagic fevers |
title_full |
Novel therapeutic targets for arenavirus hemorrhagic fevers |
title_fullStr |
Novel therapeutic targets for arenavirus hemorrhagic fevers |
title_full_unstemmed |
Novel therapeutic targets for arenavirus hemorrhagic fevers |
title_sort |
novel therapeutic targets for arenavirus hemorrhagic fevers |
url |
http://hdl.handle.net/20.500.12110/paper_17460794_v6_n1_p27_Garca |
work_keys_str_mv |
AT garcacc noveltherapeutictargetsforarenavirushemorrhagicfevers AT seplvedacs noveltherapeutictargetsforarenavirushemorrhagicfevers AT damonteeb noveltherapeutictargetsforarenavirushemorrhagicfevers |
_version_ |
1782030053825052672 |