Novel therapeutic targets for arenavirus hemorrhagic fevers

Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several th...

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Autores principales:	Garca, C.C., Seplveda, C.S., Damonte, E.B.
Formato:	JOUR
Materias:	antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_17460794_v6_n1_p27_Garca
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_17460794_v6_n1_p27_Garca2023-10-03T16:32:02Z Novel therapeutic targets for arenavirus hemorrhagic fevers Garca, C.C. Seplveda, C.S. Damonte, E.B. antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_17460794_v6_n1_p27_Garca
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus
spellingShingle	antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus Garca, C.C. Seplveda, C.S. Damonte, E.B. Novel therapeutic targets for arenavirus hemorrhagic fevers
topic_facet	antiviral agent arenavirus junin virus Lassa virus therapeutic target viral hemorrhagic fevers acridone derivative antivirus agent brassinosteroid candid 1 cell enzyme cholesterol disulfiram epiandrosterone ESCRT protein fatty acid favipiravir fluorouracil n myristolyltransferase phosphatidylserine prasterone ribavirin st 193 st 194 unclassified drug virus protein virus RNA virus vaccine virus z protein arenavirus hemorrhagic fever Argentine hemorrhagic fever article drug targeting human infection control Junin virus Lassa virus nonhuman priority journal virion virus envelope virus genome virus hemorrhagic fever Arenaviridae Arenavirus Junin virus Lassa virus
description	Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.
format	JOUR
author	Garca, C.C. Seplveda, C.S. Damonte, E.B.
author_facet	Garca, C.C. Seplveda, C.S. Damonte, E.B.
author_sort	Garca, C.C.
title	Novel therapeutic targets for arenavirus hemorrhagic fevers
title_short	Novel therapeutic targets for arenavirus hemorrhagic fevers
title_full	Novel therapeutic targets for arenavirus hemorrhagic fevers
title_fullStr	Novel therapeutic targets for arenavirus hemorrhagic fevers
title_full_unstemmed	Novel therapeutic targets for arenavirus hemorrhagic fevers
title_sort	novel therapeutic targets for arenavirus hemorrhagic fevers
url	http://hdl.handle.net/20.500.12110/paper_17460794_v6_n1_p27_Garca
work_keys_str_mv	AT garcacc noveltherapeutictargetsforarenavirushemorrhagicfevers AT seplvedacs noveltherapeutictargetsforarenavirushemorrhagicfevers AT damonteeb noveltherapeutictargetsforarenavirushemorrhagicfevers
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Novel therapeutic targets for arenavirus hemorrhagic fevers

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