Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH. © The Royal Society of Ch...

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Detalles Bibliográficos
Autores principales:	Capdevila, D.A., Álvarez-Paggi, D., Castro, M.A., Tórtora, V., Demicheli, V., Estrín, D.A., Radi, R., Murgida, D.H.
Formato:	JOUR
Materias:	cytochrome c ligand tyrosine article computational fluid dynamics computer model controlled study cyclic potentiometry deprotonation electrochemistry electron transport molecular dynamics nitration nuclear magnetic resonance spectroscopy pH proton transport Computer Simulation Cytochromes c Hydrogen-Ion Concentration Ligands Models, Molecular Nitrates Oxidation-Reduction Protons Thermodynamics Tyrosine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13597345_v50_n20_p2592_Capdevila
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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