Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH. © The Royal Society of Ch...

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Autores principales:	Capdevila, D.A., Álvarez-Paggi, D., Castro, M.A., Tórtora, V., Demicheli, V., Estrín, D.A., Radi, R., Murgida, D.H.
Formato:	JOUR
Materias:	cytochrome c ligand tyrosine article computational fluid dynamics computer model controlled study cyclic potentiometry deprotonation electrochemistry electron transport molecular dynamics nitration nuclear magnetic resonance spectroscopy pH proton transport Computer Simulation Cytochromes c Hydrogen-Ion Concentration Ligands Models, Molecular Nitrates Oxidation-Reduction Protons Thermodynamics Tyrosine
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13597345_v50_n20_p2592_Capdevila
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_13597345_v50_n20_p2592_Capdevila
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spelling	todo:paper_13597345_v50_n20_p2592_Capdevila2023-10-03T16:10:43Z Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c Capdevila, D.A. Álvarez-Paggi, D. Castro, M.A. Tórtora, V. Demicheli, V. Estrín, D.A. Radi, R. Murgida, D.H. cytochrome c ligand tyrosine article computational fluid dynamics computer model controlled study cyclic potentiometry deprotonation electrochemistry electron transport molecular dynamics nitration nuclear magnetic resonance spectroscopy pH proton transport Computer Simulation Cytochromes c Hydrogen-Ion Concentration Ligands Models, Molecular Nitrates Oxidation-Reduction Protons Thermodynamics Tyrosine Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH. © The Royal Society of Chemistry 2014. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13597345_v50_n20_p2592_Capdevila
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cytochrome c ligand tyrosine article computational fluid dynamics computer model controlled study cyclic potentiometry deprotonation electrochemistry electron transport molecular dynamics nitration nuclear magnetic resonance spectroscopy pH proton transport Computer Simulation Cytochromes c Hydrogen-Ion Concentration Ligands Models, Molecular Nitrates Oxidation-Reduction Protons Thermodynamics Tyrosine
spellingShingle	cytochrome c ligand tyrosine article computational fluid dynamics computer model controlled study cyclic potentiometry deprotonation electrochemistry electron transport molecular dynamics nitration nuclear magnetic resonance spectroscopy pH proton transport Computer Simulation Cytochromes c Hydrogen-Ion Concentration Ligands Models, Molecular Nitrates Oxidation-Reduction Protons Thermodynamics Tyrosine Capdevila, D.A. Álvarez-Paggi, D. Castro, M.A. Tórtora, V. Demicheli, V. Estrín, D.A. Radi, R. Murgida, D.H. Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
topic_facet	cytochrome c ligand tyrosine article computational fluid dynamics computer model controlled study cyclic potentiometry deprotonation electrochemistry electron transport molecular dynamics nitration nuclear magnetic resonance spectroscopy pH proton transport Computer Simulation Cytochromes c Hydrogen-Ion Concentration Ligands Models, Molecular Nitrates Oxidation-Reduction Protons Thermodynamics Tyrosine
description	Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH. © The Royal Society of Chemistry 2014.
format	JOUR
author	Capdevila, D.A. Álvarez-Paggi, D. Castro, M.A. Tórtora, V. Demicheli, V. Estrín, D.A. Radi, R. Murgida, D.H.
author_facet	Capdevila, D.A. Álvarez-Paggi, D. Castro, M.A. Tórtora, V. Demicheli, V. Estrín, D.A. Radi, R. Murgida, D.H.
author_sort	Capdevila, D.A.
title	Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
title_short	Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
title_full	Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
title_fullStr	Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
title_full_unstemmed	Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
title_sort	coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
url	http://hdl.handle.net/20.500.12110/paper_13597345_v50_n20_p2592_Capdevila
work_keys_str_mv	AT capdevilada couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT alvarezpaggid couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT castroma couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT tortorav couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT demicheliv couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT estrinda couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT radir couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec AT murgidadh couplingoftyrosinedeprotonationandaxialligandexchangeinnitrocytochromec
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Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

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