The α9/α10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear

Opioid peptides have been detected in the auditory and vestibular efferent neurons where they colocalize with the major neurotransmitter, acetylcholine. We investigated the function of opioids to modulate neurotransmission mediated by hair cell's α9/α10-containing nicotinic acetylcholine recept...

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Detalles Bibliográficos
Autores principales: Lioudyno, M.I., Verbitsky, M., Glowatzki, E., Holt, J.C., Boulter, J., Zadina, J.E., Elgoyhen, A.B., Guth, P.S.
Formato: JOUR
Materias:
acetylcholine
delta opiate receptor agonist
dynorphin B
endomorphin 1
enkephalin[2,5 dextro penicillamine]
kappa opiate receptor agonist
kappa opiate receptor antagonist
mu opiate receptor agonist
mu opiate receptor antagonist
naloxone
nicotinic receptor
opiate peptide
agents interacting with transmitter, hormone or drug receptors
dynorphin
endorphin
isoprotein
oligopeptide
opiate receptor
animal cell
animal tissue
article
competitive inhibition
controlled study
drug effect
electric current
electric potential
evoked response
female
frog
hair cell
inner ear
neurotransmission
nonhuman
oocyte
priority journal
protein expression
protein interaction
protein targeting
rat
reduction
sacculus
Xenopus
animal
chemistry
cochlea
cytology
drug antagonism
electric conductivity
frogs and toads
in vitro study
metabolism
physiology
Sprague Dawley rat
synapse
vestibule
Xenopus laevis
Animalia
Anura
Acetylcholine
Animals
Cochlea
Dynorphins
Ear, Inner
Electric Conductivity
Endorphins
Enkephalin, D-Penicillamine (2,5)-
Hair Cells
Neurotransmitter Agents
Oligopeptides
Oocytes
Protein Isoforms
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic
Receptors, Opioid
Saccule and Utricle
Synapses
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10447431_v20_n4_p695_Lioudyno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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