Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex

Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain...

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Detalles Bibliográficos
Autores principales: Lowenstein, P.R., Rosenstein, R., Cardinali, D.P.
Formato: JOUR
Materias:
4' chlorodiazepam
benzodiazepine
clonazepam
flumazenil
flunitrazepam
melatonin
radioisotope
animal cell
animal experiment
biological model
brain cortex
central nervous system
dose response
dose time effect relation
drug comparison
drug interaction
drug mechanism
drug receptor binding
drug response
endocrine system
flunitrazepam h 3
nonhuman
pharmacokinetics
priority journal
rat
subcutaneous drug administration
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01970186_v7_n4_p675_Lowenstein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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