Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex
Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_01970186_v7_n4_p675_Lowenstein |
| Aporte de: |
| id |
todo:paper_01970186_v7_n4_p675_Lowenstein |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_01970186_v7_n4_p675_Lowenstein2023-10-03T15:09:53Z Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex Lowenstein, P.R. Rosenstein, R. Cardinali, D.P. 4' chlorodiazepam benzodiazepine clonazepam flumazenil flunitrazepam melatonin radioisotope animal cell animal experiment biological model brain cortex central nervous system dose response dose time effect relation drug comparison drug interaction drug mechanism drug receptor binding drug response endocrine system flunitrazepam h 3 nonhuman pharmacokinetics priority journal rat subcutaneous drug administration Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain benzodiazepine receptor sites. Single melatonin injections (up to 1600 μg/kg) to intact rats did not affect brain benzodiazepine binding when injected at either morning or evening hours. Daily melatonin treatment to intact rats for 5 days augmented benzodiazepine receptor density in brain (morning injections) or its dissociation constant (evening injections). Melatonin added in vitro to rat cerebral cortex membranes only slightly depressed [3H]flunitrazepam binding at 100 μM concentrations. These results point out a link between pineal activity and benzodiazepine receptor function in rats. They also indicate that pharmacological doses of melatonin affect benzodiazepine binding sites in rat cerebral cortex. © 1985. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_01970186_v7_n4_p675_Lowenstein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4' chlorodiazepam benzodiazepine clonazepam flumazenil flunitrazepam melatonin radioisotope animal cell animal experiment biological model brain cortex central nervous system dose response dose time effect relation drug comparison drug interaction drug mechanism drug receptor binding drug response endocrine system flunitrazepam h 3 nonhuman pharmacokinetics priority journal rat subcutaneous drug administration |
| spellingShingle |
4' chlorodiazepam benzodiazepine clonazepam flumazenil flunitrazepam melatonin radioisotope animal cell animal experiment biological model brain cortex central nervous system dose response dose time effect relation drug comparison drug interaction drug mechanism drug receptor binding drug response endocrine system flunitrazepam h 3 nonhuman pharmacokinetics priority journal rat subcutaneous drug administration Lowenstein, P.R. Rosenstein, R. Cardinali, D.P. Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| topic_facet |
4' chlorodiazepam benzodiazepine clonazepam flumazenil flunitrazepam melatonin radioisotope animal cell animal experiment biological model brain cortex central nervous system dose response dose time effect relation drug comparison drug interaction drug mechanism drug receptor binding drug response endocrine system flunitrazepam h 3 nonhuman pharmacokinetics priority journal rat subcutaneous drug administration |
| description |
Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain benzodiazepine receptor sites. Single melatonin injections (up to 1600 μg/kg) to intact rats did not affect brain benzodiazepine binding when injected at either morning or evening hours. Daily melatonin treatment to intact rats for 5 days augmented benzodiazepine receptor density in brain (morning injections) or its dissociation constant (evening injections). Melatonin added in vitro to rat cerebral cortex membranes only slightly depressed [3H]flunitrazepam binding at 100 μM concentrations. These results point out a link between pineal activity and benzodiazepine receptor function in rats. They also indicate that pharmacological doses of melatonin affect benzodiazepine binding sites in rat cerebral cortex. © 1985. |
| format |
JOUR |
| author |
Lowenstein, P.R. Rosenstein, R. Cardinali, D.P. |
| author_facet |
Lowenstein, P.R. Rosenstein, R. Cardinali, D.P. |
| author_sort |
Lowenstein, P.R. |
| title |
Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| title_short |
Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| title_full |
Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| title_fullStr |
Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| title_full_unstemmed |
Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| title_sort |
melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| url |
http://hdl.handle.net/20.500.12110/paper_01970186_v7_n4_p675_Lowenstein |
| work_keys_str_mv |
AT lowensteinpr melatoninreversespinealectomyinduceddecreaseofbenzodiazepinebindinginratcerebralcortex AT rosensteinr melatoninreversespinealectomyinduceddecreaseofbenzodiazepinebindinginratcerebralcortex AT cardinalidp melatoninreversespinealectomyinduceddecreaseofbenzodiazepinebindinginratcerebralcortex |
| _version_ |
1782028234826711040 |