Galectin-3 negatively regulates the frequency and function of CD4 + CD25 + Foxp3 + regulatory T cells and influences the course of Leishmania major infection

Galectin-3, an endogenous glycan-binding protein, plays essential roles during microbial infection by modulating innate and adaptive immunity. However, the role of galectin-3 within the CD4 + CD25 + Foxp3 + T regulatory (T REG ) cell compartment has not yet been explored. Here, we found, in a model...

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Detalles Bibliográficos
Autores principales: Fermino, M.L., Dias, F.C., Lopes, C.D., Souza, M.A., Cruz, A.K., Liu, F.-T., Chammas, R., Roque-Barreira, M.C., Rabinovich, G.A., Bernardes, E.S.
Formato: JOUR
Materias:
Galectin-3
IL-10
Leishmania major
Notch signaling
T regulatory (Treg) cells
CD103 antigen
galectin 3
gamma interferon
interleukin 10
interleukin 4
Notch1 receptor
transcription factor FOXP3
transcription factor HES 1
animal experiment
animal model
animal tissue
antigen expression
article
CD4+ CD25+ T lymphocyte
controlled study
disease course
disease severity
effector cell
flow cytometry
immunohistochemistry
in vitro study
leishmaniasis
lymph node
lymphocyte function
mouse
negative feedback
nonhuman
parasite load
priority journal
regulatory T lymphocyte
wild type
Animals
Disease Models, Animal
Flow Cytometry
Forkhead Transcription Factors
Galectin 3
Immunohistochemistry
Leishmaniasis, Cutaneous
Mice
Mice, Inbred BALB C
Mice, Knockout
Real-Time Polymerase Chain Reaction
Receptors, Notch
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes, Regulatory
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142980_v43_n7_p1806_Fermino
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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