Performance of alginate films for retention of l-(+)-ascorbic acid

Mostrar todas las versiones(2)

In view of acting as controlled delivery systems for nutritional supplementation, therapy or antioxidant activity at interfaces, alginate films of different copolymer composition and glycerol plasticizer levels were developed in the presence of Ca2+ for achieving higher stability of l-(+)-ascorbic a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Soria, Marcelo Abel, Fissore, Eliana Noemí, Rojas, Ana María Luisa
Publicado:	2013
Materias:	Alginate films Antioxidant interface Ascorbic acid hydrolysis Biomolecule delivery Glycerol alginic acid ascorbic acid calcium alginate glycerol mannuronic acid water article drug hydrolysis drug stability humidity molecule priority journal temperature Alginates Ascorbic Acid Drug Stability Drug Storage Humidity Hydrolysis Oxidation-Reduction Plasticizers
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v450_n1-2_p95_DeNobili http://hdl.handle.net/20.500.12110/paper_03785173_v450_n1-2_p95_DeNobili
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03785173_v450_n1-2_p95_DeNobili
record_format	dspace
spelling	paper:paper_03785173_v450_n1-2_p95_DeNobili2023-06-08T15:40:23Z Performance of alginate films for retention of l-(+)-ascorbic acid Soria, Marcelo Abel Fissore, Eliana Noemí Rojas, Ana María Luisa Alginate films Antioxidant interface Ascorbic acid hydrolysis Biomolecule delivery Glycerol alginic acid ascorbic acid calcium alginate glycerol mannuronic acid water article drug hydrolysis drug stability humidity molecule priority journal temperature Alginates Ascorbic Acid Drug Stability Drug Storage Glycerol Humidity Hydrolysis Oxidation-Reduction Plasticizers In view of acting as controlled delivery systems for nutritional supplementation, therapy or antioxidant activity at interfaces, alginate films of different copolymer composition and glycerol plasticizer levels were developed in the presence of Ca2+ for achieving higher stability of l-(+)-ascorbic acid (AA). The ability of the alginate network to preserve AA from hydrolysis, tested by storage under vacuum at 25 C, only decreased with the relative humidity (RH) increase when alginates were mainly constituted by guluronic-guluronic acid blocks (GG), whereas also decreased with the glycerol level increase when mannuronic-mannuronic acid (MM) and/or alternating guluronic-mannuronic (GM + MG) flexible blocks were present in higher proportions. This result could be probably related to the lower capability of the latter alginate block compositions to immobilize water in the network as they are not able to constitute Ca2+ mediated junction zones where water molecules are highly retained. Films also studied under air storage showed that even at less favorable conditions of RH and glycerol levels, both GG and GM + MG enriched alginate networks in general preserved AA from oxidation. It also demonstrated that hydrolysis is the principal way by which AA is lost when supported in films. © 2013 Elsevier B.V. Fil:Soria, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fissore, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rojas, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v450_n1-2_p95_DeNobili http://hdl.handle.net/20.500.12110/paper_03785173_v450_n1-2_p95_DeNobili
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alginate films Antioxidant interface Ascorbic acid hydrolysis Biomolecule delivery Glycerol alginic acid ascorbic acid calcium alginate glycerol mannuronic acid water article drug hydrolysis drug stability humidity molecule priority journal temperature Alginates Ascorbic Acid Drug Stability Drug Storage Glycerol Humidity Hydrolysis Oxidation-Reduction Plasticizers
spellingShingle	Alginate films Antioxidant interface Ascorbic acid hydrolysis Biomolecule delivery Glycerol alginic acid ascorbic acid calcium alginate glycerol mannuronic acid water article drug hydrolysis drug stability humidity molecule priority journal temperature Alginates Ascorbic Acid Drug Stability Drug Storage Glycerol Humidity Hydrolysis Oxidation-Reduction Plasticizers Soria, Marcelo Abel Fissore, Eliana Noemí Rojas, Ana María Luisa Performance of alginate films for retention of l-(+)-ascorbic acid
topic_facet	Alginate films Antioxidant interface Ascorbic acid hydrolysis Biomolecule delivery Glycerol alginic acid ascorbic acid calcium alginate glycerol mannuronic acid water article drug hydrolysis drug stability humidity molecule priority journal temperature Alginates Ascorbic Acid Drug Stability Drug Storage Glycerol Humidity Hydrolysis Oxidation-Reduction Plasticizers
description	In view of acting as controlled delivery systems for nutritional supplementation, therapy or antioxidant activity at interfaces, alginate films of different copolymer composition and glycerol plasticizer levels were developed in the presence of Ca2+ for achieving higher stability of l-(+)-ascorbic acid (AA). The ability of the alginate network to preserve AA from hydrolysis, tested by storage under vacuum at 25 C, only decreased with the relative humidity (RH) increase when alginates were mainly constituted by guluronic-guluronic acid blocks (GG), whereas also decreased with the glycerol level increase when mannuronic-mannuronic acid (MM) and/or alternating guluronic-mannuronic (GM + MG) flexible blocks were present in higher proportions. This result could be probably related to the lower capability of the latter alginate block compositions to immobilize water in the network as they are not able to constitute Ca2+ mediated junction zones where water molecules are highly retained. Films also studied under air storage showed that even at less favorable conditions of RH and glycerol levels, both GG and GM + MG enriched alginate networks in general preserved AA from oxidation. It also demonstrated that hydrolysis is the principal way by which AA is lost when supported in films. © 2013 Elsevier B.V.
author	Soria, Marcelo Abel Fissore, Eliana Noemí Rojas, Ana María Luisa
author_facet	Soria, Marcelo Abel Fissore, Eliana Noemí Rojas, Ana María Luisa
author_sort	Soria, Marcelo Abel
title	Performance of alginate films for retention of l-(+)-ascorbic acid
title_short	Performance of alginate films for retention of l-(+)-ascorbic acid
title_full	Performance of alginate films for retention of l-(+)-ascorbic acid
title_fullStr	Performance of alginate films for retention of l-(+)-ascorbic acid
title_full_unstemmed	Performance of alginate films for retention of l-(+)-ascorbic acid
title_sort	performance of alginate films for retention of l-(+)-ascorbic acid
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785173_v450_n1-2_p95_DeNobili http://hdl.handle.net/20.500.12110/paper_03785173_v450_n1-2_p95_DeNobili
work_keys_str_mv	AT soriamarceloabel performanceofalginatefilmsforretentionoflascorbicacid AT fissoreeliananoemi performanceofalginatefilmsforretentionoflascorbicacid AT rojasanamarialuisa performanceofalginatefilmsforretentionoflascorbicacid
_version_	1768545332171374592

Performance of alginate films for retention of l-(+)-ascorbic acid

Ejemplares similares