Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) α and β subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH fu...

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Detalles Bibliográficos
Publicado: 2007
Materias:
Knockout
Luteinising hormone
Luteinising hormone receptor
Luteoma
Ovary
Pituitary gland
Prolactinoma
Testis
Transgenic
Tumorigenesis
chorionic gonadotropin
luteinizing hormone
dimerization
gene function
gene targeting
genomics
nonhuman
phenotype
priority journal
receptor binding
review
signal transduction
Animals
Chorionic Gonadotropin
Gene Expression
Genitalia
Humans
Luteinizing Hormone
Mice
Mice, Knockout
Phenotype
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v260-262_n_p255_Ahtiainen
http://hdl.handle.net/20.500.12110/paper_03037207_v260-262_n_p255_Ahtiainen
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) α and β subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models. © 2006 Elsevier Ireland Ltd. All rights reserved.

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