Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) α and β subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH fu...

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Detalles Bibliográficos
Publicado: 2007
Materias:
Knockout
Luteinising hormone
Luteinising hormone receptor
Luteoma
Ovary
Pituitary gland
Prolactinoma
Testis
Transgenic
Tumorigenesis
chorionic gonadotropin
luteinizing hormone
dimerization
gene function
gene targeting
genomics
nonhuman
phenotype
priority journal
receptor binding
review
signal transduction
Animals
Chorionic Gonadotropin
Gene Expression
Genitalia
Humans
Luteinizing Hormone
Mice
Mice, Knockout
Phenotype
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v260-262_n_p255_Ahtiainen
http://hdl.handle.net/20.500.12110/paper_03037207_v260-262_n_p255_Ahtiainen
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03037207_v260-262_n_p255_Ahtiainen
record_format dspace
spelling paper:paper_03037207_v260-262_n_p255_Ahtiainen2023-06-08T15:29:06Z Phenotypic characterisation of mice with exaggerated and missing LH/hCG action Knockout Luteinising hormone Luteinising hormone receptor Luteoma Ovary Pituitary gland Prolactinoma Testis Transgenic Tumorigenesis chorionic gonadotropin luteinizing hormone dimerization gene function gene targeting genomics nonhuman phenotype priority journal receptor binding review signal transduction Animals Chorionic Gonadotropin Gene Expression Genitalia Humans Luteinizing Hormone Mice Mice, Knockout Phenotype In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) α and β subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models. © 2006 Elsevier Ireland Ltd. All rights reserved. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v260-262_n_p255_Ahtiainen http://hdl.handle.net/20.500.12110/paper_03037207_v260-262_n_p255_Ahtiainen
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Knockout
Luteinising hormone
Luteinising hormone receptor
Luteoma
Ovary
Pituitary gland
Prolactinoma
Testis
Transgenic
Tumorigenesis
chorionic gonadotropin
luteinizing hormone
dimerization
gene function
gene targeting
genomics
nonhuman
phenotype
priority journal
receptor binding
review
signal transduction
Animals
Chorionic Gonadotropin
Gene Expression
Genitalia
Humans
Luteinizing Hormone
Mice
Mice, Knockout
Phenotype
spellingShingle Knockout
Luteinising hormone
Luteinising hormone receptor
Luteoma
Ovary
Pituitary gland
Prolactinoma
Testis
Transgenic
Tumorigenesis
chorionic gonadotropin
luteinizing hormone
dimerization
gene function
gene targeting
genomics
nonhuman
phenotype
priority journal
receptor binding
review
signal transduction
Animals
Chorionic Gonadotropin
Gene Expression
Genitalia
Humans
Luteinizing Hormone
Mice
Mice, Knockout
Phenotype
Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
topic_facet Knockout
Luteinising hormone
Luteinising hormone receptor
Luteoma
Ovary
Pituitary gland
Prolactinoma
Testis
Transgenic
Tumorigenesis
chorionic gonadotropin
luteinizing hormone
dimerization
gene function
gene targeting
genomics
nonhuman
phenotype
priority journal
receptor binding
review
signal transduction
Animals
Chorionic Gonadotropin
Gene Expression
Genitalia
Humans
Luteinizing Hormone
Mice
Mice, Knockout
Phenotype
description In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) α and β subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models. © 2006 Elsevier Ireland Ltd. All rights reserved.
title Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_short Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_full Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_fullStr Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_full_unstemmed Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_sort phenotypic characterisation of mice with exaggerated and missing lh/hcg action
publishDate 2007
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v260-262_n_p255_Ahtiainen
http://hdl.handle.net/20.500.12110/paper_03037207_v260-262_n_p255_Ahtiainen
_version_ 1768543368631025664

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