A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one

The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone d...

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Detalles Bibliográficos
Autores principales:	Revelli, Gustavo Ariel, Gros, Eduardo Gervasio
Publicado:	1993
Materias:	4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one androstane derivative unclassified drug article drug synthesis nuclear magnetic resonance
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v23_n8_p1111_Revelli http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00397911_v23_n8_p1111_Revelli
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spelling	paper:paper_00397911_v23_n8_p1111_Revelli2023-06-08T15:03:39Z A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one Revelli, Gustavo Ariel Gros, Eduardo Gervasio 4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one androstane derivative unclassified drug article drug synthesis nuclear magnetic resonance The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone derivative (2). © 1993, Taylor & Francis Group, LLC. All rights reserved. Fil:Revelli, G.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v23_n8_p1111_Revelli http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one androstane derivative unclassified drug article drug synthesis nuclear magnetic resonance
spellingShingle	4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one androstane derivative unclassified drug article drug synthesis nuclear magnetic resonance Revelli, Gustavo Ariel Gros, Eduardo Gervasio A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
topic_facet	4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one androstane derivative unclassified drug article drug synthesis nuclear magnetic resonance
description	The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone derivative (2). © 1993, Taylor & Francis Group, LLC. All rights reserved.
author	Revelli, Gustavo Ariel Gros, Eduardo Gervasio
author_facet	Revelli, Gustavo Ariel Gros, Eduardo Gervasio
author_sort	Revelli, Gustavo Ariel
title	A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_short	A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_full	A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_fullStr	A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_full_unstemmed	A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_sort	facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v23_n8_p1111_Revelli http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli
work_keys_str_mv	AT revelligustavoariel afacilesynthesisof43bmethoxy5aandrostan17byl3pyrrolin2one AT groseduardogervasio afacilesynthesisof43bmethoxy5aandrostan17byl3pyrrolin2one AT revelligustavoariel facilesynthesisof43bmethoxy5aandrostan17byl3pyrrolin2one AT groseduardogervasio facilesynthesisof43bmethoxy5aandrostan17byl3pyrrolin2one
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A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one

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