A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one

The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone d...

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Detalles Bibliográficos
Autores principales: Revelli, Gustavo Ariel, Gros, Eduardo Gervasio
Publicado: 1993
Materias:
4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one
androstane derivative
unclassified drug
article
drug synthesis
nuclear magnetic resonance
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v23_n8_p1111_Revelli
http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00397911_v23_n8_p1111_Revelli
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spelling paper:paper_00397911_v23_n8_p1111_Revelli2023-06-08T15:03:39Z A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one Revelli, Gustavo Ariel Gros, Eduardo Gervasio 4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one androstane derivative unclassified drug article drug synthesis nuclear magnetic resonance The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone derivative (2). © 1993, Taylor & Francis Group, LLC. All rights reserved. Fil:Revelli, G.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v23_n8_p1111_Revelli http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic 4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one
androstane derivative
unclassified drug
article
drug synthesis
nuclear magnetic resonance
spellingShingle 4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one
androstane derivative
unclassified drug
article
drug synthesis
nuclear magnetic resonance
Revelli, Gustavo Ariel
Gros, Eduardo Gervasio
A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
topic_facet 4 (3beta methoxy 5alpha androstan 17beta yl) 3 pyrrolin 2 one
androstane derivative
unclassified drug
article
drug synthesis
nuclear magnetic resonance
description The title compound was prepared in 4 steps from 3β-methoxy-21- hydroxy-5α-pregnan-20-one (1). The required intermediate (4) was obtained using lithium enolate derived from t-butyl acetate. Interesting enough, p-tosyl chloride in pyridine quantitatively converted compound 1 into the a-chloro ketone derivative (2). © 1993, Taylor & Francis Group, LLC. All rights reserved.
author Revelli, Gustavo Ariel
Gros, Eduardo Gervasio
author_facet Revelli, Gustavo Ariel
Gros, Eduardo Gervasio
author_sort Revelli, Gustavo Ariel
title A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_short A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_full A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_fullStr A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_full_unstemmed A facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
title_sort facile synthesis of 4-(3β -methoxy-5α -androstan-17β -yl)- 3-pyrrolin-2-one
publishDate 1993
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00397911_v23_n8_p1111_Revelli
http://hdl.handle.net/20.500.12110/paper_00397911_v23_n8_p1111_Revelli
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