Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom

The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain-blood barrier (BBB) imposes, the interplay between these two systems requires a variety of delicate anatomical...

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Detalles Bibliográficos
Autores principales: Cabral, Agustina Soledad, De Francesco, Pablo Nicolás, Perelló, Mario
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Ciencias Médicas
Appetite
Brain accessibility
Food intake
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98286
https://ri.conicet.gov.ar/11336/54434
https://www.frontiersin.org/articles/10.3389/fendo.2015.00044/full
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98286
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Appetite
Brain accessibility
Food intake
spellingShingle Ciencias Exactas
Ciencias Médicas
Appetite
Brain accessibility
Food intake
Cabral, Agustina Soledad
De Francesco, Pablo Nicolás
Perelló, Mario
Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
topic_facet Ciencias Exactas
Ciencias Médicas
Appetite
Brain accessibility
Food intake
description The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain-blood barrier (BBB) imposes, the interplay between these two systems requires a variety of delicate anatomical interfaces and physiological mechanisms that guarantee the precise function of the neuroendocrine system as a whole. The study of the mechanisms by which hormones act in the brain in order to regulate specific neuronal populations is a research topic rather neglected. Our group studies the neuronal circuitries and molecular mechanisms by which the stomach-produced hormone ghrelin regulates appetite and other physiological functions. A clear notion of the brain targets of peripheral ghrelin is essential for the comprehensive understanding of the physiological role of this hormone. Ghrelin is called "the hunger hormone" since it is the only known orexigenic peptide hormone. The target for ghrelin orexigenic actions is the brain, which contains a variety of ghrelin-responsive nuclei; however, several evidences suggest that the accessibility of peripheral ghrelin to the brain is strikingly low. Here, we briefly summarize the current knowledge in this topic and discuss this intriguing neuroendocrinological issue.
format Articulo
Comunicacion
author Cabral, Agustina Soledad
De Francesco, Pablo Nicolás
Perelló, Mario
author_facet Cabral, Agustina Soledad
De Francesco, Pablo Nicolás
Perelló, Mario
author_sort Cabral, Agustina Soledad
title Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
title_short Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
title_full Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
title_fullStr Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
title_full_unstemmed Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
title_sort brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/98286
https://ri.conicet.gov.ar/11336/54434
https://www.frontiersin.org/articles/10.3389/fendo.2015.00044/full
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