Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer

Angiogenesis is an essential process in the progression of malignant tumors and the most potent angiogenic factor is the vascular endothelial growth factor (VEGF). On the other hand, the CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a dir...

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Detalles Bibliográficos
Autores principales: Inda, Ana María, Andrini, Laura Beatriz, García, Marcela Nilda, García, Adriana L., Fernández Blanco, Ayelén, Furnus, Cecilia Cristina, Galletti, S., Prat, Guillermo Daniel, Errecalde, Ana Lía
Formato: Articulo
Lenguaje:Inglés
Publicado: 2007
Materias:
Ciencias Médicas
Lung cancer
Vegf
Antígenos CD34
Angiogenesis
Epidermoid carcinoma
Adenocarcinoma
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/96849
https://ri.conicet.gov.ar/11336/83597
http://www.ncbi.nlm.nih.gov/pubmed/17987799
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-96849
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Lung cancer
Vegf
Antígenos CD34
Angiogenesis
Epidermoid carcinoma
Adenocarcinoma
spellingShingle Ciencias Médicas
Lung cancer
Vegf
Antígenos CD34
Angiogenesis
Epidermoid carcinoma
Adenocarcinoma
Inda, Ana María
Andrini, Laura Beatriz
García, Marcela Nilda
García, Adriana L.
Fernández Blanco, Ayelén
Furnus, Cecilia Cristina
Galletti, S.
Prat, Guillermo Daniel
Errecalde, Ana Lía
Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer
topic_facet Ciencias Médicas
Lung cancer
Vegf
Antígenos CD34
Angiogenesis
Epidermoid carcinoma
Adenocarcinoma
description Angiogenesis is an essential process in the progression of malignant tumors and the most potent angiogenic factor is the vascular endothelial growth factor (VEGF). On the other hand, the CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a direct marker of the degree of neoangiogenesis. In the present study we report the VEGF expression and its relationship with MVD, measured by CD34, in two lineages of non-small cell lung cancer (NSCL): low differentiated adenocarcinomas and epidermoid carcinomas, in order to consider the possibility of using the correlation between both antibodies as a prognostic factor. Tumor sections were stained by immunohistochemistry for CD34 and VEGF. The results showed that the mean value of VEGF for adenocarcinoma was significantly higher than the one for epidermoid carcinoma (p < 0.001). However, the mean of MVD did not show significant differences between both types of tumors. The conventional factors taken into consideration (age over 60, sex, and presence of lymph nodes) was not significantly related to the angiogenic factors examined. In conclusion, we could affirm that CD34 is a better prognostic marker of neoangiogenesis in NSCLC, because both types of tumors have the same clinical prognosis, and so we expected the same behaviour from both markers.
format Articulo
Articulo
author Inda, Ana María
Andrini, Laura Beatriz
García, Marcela Nilda
García, Adriana L.
Fernández Blanco, Ayelén
Furnus, Cecilia Cristina
Galletti, S.
Prat, Guillermo Daniel
Errecalde, Ana Lía
author_facet Inda, Ana María
Andrini, Laura Beatriz
García, Marcela Nilda
García, Adriana L.
Fernández Blanco, Ayelén
Furnus, Cecilia Cristina
Galletti, S.
Prat, Guillermo Daniel
Errecalde, Ana Lía
author_sort Inda, Ana María
title Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer
title_short Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer
title_full Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer
title_fullStr Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer
title_full_unstemmed Evaluation of angiogenesis with the expression of VEGF and CD34 in human non-small cell lung cancer
title_sort evaluation of angiogenesis with the expression of vegf and cd34 in human non-small cell lung cancer
publishDate 2007
url http://sedici.unlp.edu.ar/handle/10915/96849
https://ri.conicet.gov.ar/11336/83597
http://www.ncbi.nlm.nih.gov/pubmed/17987799
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