Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish

Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone,...

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Detalles Bibliográficos
Autores principales: Prieto, María Jimena, Carreno Gutiérrez, Héctor, Arévalo Arévalo, Rosario, Chiaramoni, Nadia Silvia, Alonso, Silvia del Valle
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/95713
https://ri.conicet.gov.ar/11336/70794
https://file.scirp.org/Html/4-1790020_26234.htm
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-95713
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
spellingShingle Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
Prieto, María Jimena
Carreno Gutiérrez, Héctor
Arévalo Arévalo, Rosario
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
topic_facet Biología
Zebrafish
Risperidone
Fluoxetine
Serotonine
Behavioral
description Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.
format Articulo
Articulo
author Prieto, María Jimena
Carreno Gutiérrez, Héctor
Arévalo Arévalo, Rosario
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author_facet Prieto, María Jimena
Carreno Gutiérrez, Héctor
Arévalo Arévalo, Rosario
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author_sort Prieto, María Jimena
title Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_short Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_full Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_fullStr Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_full_unstemmed Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
title_sort effect of risperidone and fluoxetine on the movement and neurochemical changes of zebrafish
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/95713
https://ri.conicet.gov.ar/11336/70794
https://file.scirp.org/Html/4-1790020_26234.htm
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