Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report

In January 2015, a 20-month-old child and her family took part in recreational activities at Carrasco and Malvín beaches (Montevideo, Uruguay). An intense harmful algae bloom (HAB) was developing along the coast at that time. A few hours after the last recreational exposure episode, the family suffe...

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Autores principales: Vidal, Flavia, Sedan, Daniela, D’Agostino, Daniel, Cavalieri, María Lorena, Mullen, Eduardo, Parot Varela, María Macarena, Flores, Cintia, Caixach, Josep, Andrinolo, Darío
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
Cyanobacteria
Liver failure
Microcystins
Recreational exposure
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87459
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87459
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Cyanobacteria
Liver failure
Microcystins
Recreational exposure
spellingShingle Ciencias Exactas
Cyanobacteria
Liver failure
Microcystins
Recreational exposure
Vidal, Flavia
Sedan, Daniela
D’Agostino, Daniel
Cavalieri, María Lorena
Mullen, Eduardo
Parot Varela, María Macarena
Flores, Cintia
Caixach, Josep
Andrinolo, Darío
Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report
topic_facet Ciencias Exactas
Cyanobacteria
Liver failure
Microcystins
Recreational exposure
description In January 2015, a 20-month-old child and her family took part in recreational activities at Carrasco and Malvín beaches (Montevideo, Uruguay). An intense harmful algae bloom (HAB) was developing along the coast at that time. A few hours after the last recreational exposure episode, the family suffered gastrointestinal symptoms which were self-limited except in the child’s case, who was admitted to hospital in Uruguay with diarrhea, vomiting, fatigue, and jaundice. The patient had increased serum levels of liver enzymes and bilirubin and five days later presented acute liver failure. She was referred to the Italian Hospital in Buenos Aires, being admitted with grade II-III encephalopathy and hepatomegaly and requiring mechanical respiratory assistance. Serology tests for hepatitis A, B, and C, Epstein-Barr virus, and cytomegalovirus were negative. Laboratory features showed anemia, coagulopathy, and increased serum levels of ammonium, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin. Autoimmune Hepatitis Type-II (AH-II) was the initial diagnosis based on a liver kidney microsomal type 1 antibodies (LKM-1) positive result, and twenty days later a liver transplant was performed. The liver histopathology had indicated hemorrhagic necrosis in zone 3, and cholestasis and nodular regeneration, which were not characteristic of AH-II. LC/ESI-HRMS (liquid chromatography electrospray ionization high-resolution mass spectrometry) analysis of MCs in the explanted liver revealed the presence of Microsytin-LR (MC-LR) (2.4 ng·gr-1 tissue) and [D-Leu1]MC-LR (75.4 ng·gr-1 tissue), which constitute a toxicological nexus and indicate a preponderant role of microcystins in the development of fulminant hepatitis.
format Articulo
Articulo
author Vidal, Flavia
Sedan, Daniela
D’Agostino, Daniel
Cavalieri, María Lorena
Mullen, Eduardo
Parot Varela, María Macarena
Flores, Cintia
Caixach, Josep
Andrinolo, Darío
author_facet Vidal, Flavia
Sedan, Daniela
D’Agostino, Daniel
Cavalieri, María Lorena
Mullen, Eduardo
Parot Varela, María Macarena
Flores, Cintia
Caixach, Josep
Andrinolo, Darío
author_sort Vidal, Flavia
title Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report
title_short Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report
title_full Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report
title_fullStr Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report
title_full_unstemmed Recreational exposure during algal bloom in Carrasco beach,Uruguay: a liver failure case report
title_sort recreational exposure during algal bloom in carrasco beach,uruguay: a liver failure case report
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87459
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