Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria

Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC) of male and female mice during early postnatal life,...

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Autores principales: Acaz Fonseca, Estefanía, Ortiz Rodriguez, Ana, Lopez Rodriguez, Ana B., Garcia Segura, Luis M., Astiz, Mariana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
Cardiolipin
Sex differences
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87344
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87344
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Cardiolipin
Sex differences
spellingShingle Ciencias Médicas
Cardiolipin
Sex differences
Acaz Fonseca, Estefanía
Ortiz Rodriguez, Ana
Lopez Rodriguez, Ana B.
Garcia Segura, Luis M.
Astiz, Mariana
Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
topic_facet Ciencias Médicas
Cardiolipin
Sex differences
description Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC) of male and female mice during early postnatal life, when sex steroids induce sex-dimorphic maturation of the brain. Despite the fact that total amount of CL was similar, its fatty acid composition differed between males and females at birth. In males, CL was more mature (lower saturation ratio) and the expression of the enzymes involved in synthetic and remodeling pathways was higher, compared to females. Importantly, the sex differences found in CL metabolism were due to the testosterone peak that male mice experience perinatally. These changes were associated with a higher expression of UCP-2 and its activators in the CC of males. Overall, our results suggest that the perinatal testosterone surge in male mice regulates CL biosynthesis and remodeling in the CC, inducing a sex-dimorphic fatty acid composition. In male's CC, CL is more susceptible to peroxidation, likely explaining the testosterone-dependent induction of neuroprotective molecules such as UCP-2. These differences may account for the sex-dependent mitochondrial susceptibility after perinatal hypoxia/ischemia.
format Articulo
Articulo
author Acaz Fonseca, Estefanía
Ortiz Rodriguez, Ana
Lopez Rodriguez, Ana B.
Garcia Segura, Luis M.
Astiz, Mariana
author_facet Acaz Fonseca, Estefanía
Ortiz Rodriguez, Ana
Lopez Rodriguez, Ana B.
Garcia Segura, Luis M.
Astiz, Mariana
author_sort Acaz Fonseca, Estefanía
title Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
title_short Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
title_full Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
title_fullStr Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
title_full_unstemmed Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
title_sort developmental sex differences in the metabolism of cardiolipin in mouse cerebral cortex mitochondria
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87344
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