An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti

The influences of reaction parameters on the etherification of phenols to obtain 1-bromo-2-aryloxyethane derivatives were evaluated. The compounds were prepared by direct etherification of phenols with 1,2-dibromoethane using anhydrous K2CO3 and acetonitrile as solvent reaction, at 80°C, in a reacti...

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Autores principales: Pájaro, Yina, Sathicq, Ángel Gabriel, Puello-Polo, Esneyder, Pérez, Astrid, Romanelli, Gustavo Pablo, Trilleras, Jorge
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Química
Phenols
Etherification
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87172
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87172
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Phenols
Etherification
spellingShingle Química
Phenols
Etherification
Pájaro, Yina
Sathicq, Ángel Gabriel
Puello-Polo, Esneyder
Pérez, Astrid
Romanelli, Gustavo Pablo
Trilleras, Jorge
An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti
topic_facet Química
Phenols
Etherification
description The influences of reaction parameters on the etherification of phenols to obtain 1-bromo-2-aryloxyethane derivatives were evaluated. The compounds were prepared by direct etherification of phenols with 1,2-dibromoethane using anhydrous K2CO3 and acetonitrile as solvent reaction, at 80°C, in a reaction time of 6 h. Under these conditions, excellent yields (71%-94%) were obtained, with low yields of secondary products. The anhydrous K2CO3 was recycled by simple filtration, dried in vacuum, and reused. The compounds were characterized by conventional spectral data (MS and NMR). Larvicidal activity results showed a 100% larval mortality after 24-hour exposure to the compound 1-(2-bromoethoxy)-2-phenylbenzene.
format Articulo
Articulo
author Pájaro, Yina
Sathicq, Ángel Gabriel
Puello-Polo, Esneyder
Pérez, Astrid
Romanelli, Gustavo Pablo
Trilleras, Jorge
author_facet Pájaro, Yina
Sathicq, Ángel Gabriel
Puello-Polo, Esneyder
Pérez, Astrid
Romanelli, Gustavo Pablo
Trilleras, Jorge
author_sort Pájaro, Yina
title An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti
title_short An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti
title_full An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti
title_fullStr An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti
title_full_unstemmed An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti
title_sort efficient k2co3-promoted synthesis of 1-bromo-2-aryloxyethane derivatives and evaluation of larval mortality against aedes aegypti
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87172
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