Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony

In humans, the knowledge of intracranial correlates of spindles is mainly gathered from noninvasive neurophysiologic and functional imaging studies which provide an indirect estimate of neuronal intracranial activity. This potential limitation can be overcome by intracranial electroencephalography u...

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Detalles Bibliográficos
Autores principales: Frauscher, Birgit, Ellenrieder, Nicolás von, Dubeau, François, Gotman, Jean
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ingeniería Electrónica
Electroencephalography
Hippocampus
Human
Insula
Non-rapid eye movement sleep
Sleep physiology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86787
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86787
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería Electrónica
Electroencephalography
Hippocampus
Human
Insula
Non-rapid eye movement sleep
Sleep physiology
spellingShingle Ingeniería Electrónica
Electroencephalography
Hippocampus
Human
Insula
Non-rapid eye movement sleep
Sleep physiology
Frauscher, Birgit
Ellenrieder, Nicolás von
Dubeau, François
Gotman, Jean
Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
topic_facet Ingeniería Electrónica
Electroencephalography
Hippocampus
Human
Insula
Non-rapid eye movement sleep
Sleep physiology
description In humans, the knowledge of intracranial correlates of spindles is mainly gathered from noninvasive neurophysiologic and functional imaging studies which provide an indirect estimate of neuronal intracranial activity. This potential limitation can be overcome by intracranial electroencephalography used in presurgical epilepsy evaluation. We investigated the intracranial correlates of scalp spindles using combined scalp and intracerebral depth electrodes covering the frontal, parietal and temporal neocortex, and the scalp and intracranial correlates of hippocampal and insula spindles in 35 pre-surgical epilepsy patients. Spindles in the scalp were accompanied by widespread cortical increases in sigma band energy (10-16. Hz): the highest percentages were observed in the frontoparietal lateral and mesial cortex, whereas in temporal lateral and mesial structures only a low or no simultaneous increase was present. This intracranial involvement during scalp spindles showed no consistent pattern, and exhibited unexpectedly low synchrony across brain regions. Hippocampal spindles were shorter and spatially restricted with a low synchrony even within the temporal lobe. Similar results were found for the insula. We suggest that the generation of spindles is under a high local cortical influence contributing to the concept of sleep as a local phenomenon and challenging the notion of spindles as widespread synchronous oscillations.
format Articulo
Articulo
author Frauscher, Birgit
Ellenrieder, Nicolás von
Dubeau, François
Gotman, Jean
author_facet Frauscher, Birgit
Ellenrieder, Nicolás von
Dubeau, François
Gotman, Jean
author_sort Frauscher, Birgit
title Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
title_short Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
title_full Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
title_fullStr Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
title_full_unstemmed Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
title_sort scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86787
work_keys_str_mv AT frauscherbirgit scalpspindlesareassociatedwithwidespreadintracranialactivitywithunexpectedlylowsynchrony
AT ellenriedernicolasvon scalpspindlesareassociatedwithwidespreadintracranialactivitywithunexpectedlylowsynchrony
AT dubeaufrancois scalpspindlesareassociatedwithwidespreadintracranialactivitywithunexpectedlylowsynchrony
AT gotmanjean scalpspindlesareassociatedwithwidespreadintracranialactivitywithunexpectedlylowsynchrony
bdutipo_str Repositorios
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