Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains

The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susc...

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Detalles Bibliográficos
Autores principales: Negrotto, Soledad, Mena, Hebe A., Ure, Agustín Enrique, Jaquenod De Giusti, Carolina, Bollati Fogolín, Mariela, Vermeulen, Elba M., Schattner, Mirta, Gómez, Ricardo Martín
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86431
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86431
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
spellingShingle Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
Negrotto, Soledad
Mena, Hebe A.
Ure, Agustín Enrique
Jaquenod De Giusti, Carolina
Bollati Fogolín, Mariela
Vermeulen, Elba M.
Schattner, Mirta
Gómez, Ricardo Martín
Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
topic_facet Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
description The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.
format Articulo
Articulo
author Negrotto, Soledad
Mena, Hebe A.
Ure, Agustín Enrique
Jaquenod De Giusti, Carolina
Bollati Fogolín, Mariela
Vermeulen, Elba M.
Schattner, Mirta
Gómez, Ricardo Martín
author_facet Negrotto, Soledad
Mena, Hebe A.
Ure, Agustín Enrique
Jaquenod De Giusti, Carolina
Bollati Fogolín, Mariela
Vermeulen, Elba M.
Schattner, Mirta
Gómez, Ricardo Martín
author_sort Negrotto, Soledad
title Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_short Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_full Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_fullStr Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_full_unstemmed Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains
title_sort human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic junin virus strains
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86431
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