Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina

Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins...

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Autores principales: Santos, María Rita, Ramallo, Virginia, Muzzio, Marina, López Camelo, Jorge Santiago, Bailliet, Graciela
Formato: Articulo
Lenguaje:Español
Publicado: 2015
Materias:
Ciencias Naturales
Arylamine N-acetyltransferase
Cleft lip
Cleft palate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86112
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86112
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Naturales
Arylamine N-acetyltransferase
Cleft lip
Cleft palate
spellingShingle Ciencias Naturales
Arylamine N-acetyltransferase
Cleft lip
Cleft palate
Santos, María Rita
Ramallo, Virginia
Muzzio, Marina
López Camelo, Jorge Santiago
Bailliet, Graciela
Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
topic_facet Ciencias Naturales
Arylamine N-acetyltransferase
Cleft lip
Cleft palate
description Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP. Material and Methods: We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT). Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio = 1,6; p = 0,03). Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP.
format Articulo
Articulo
author Santos, María Rita
Ramallo, Virginia
Muzzio, Marina
López Camelo, Jorge Santiago
Bailliet, Graciela
author_facet Santos, María Rita
Ramallo, Virginia
Muzzio, Marina
López Camelo, Jorge Santiago
Bailliet, Graciela
author_sort Santos, María Rita
title Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
title_short Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
title_full Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
title_fullStr Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
title_full_unstemmed Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina
title_sort asociación entre polimorfismos del gen nat2 y fisura labiopalatina no sindrómica en argentina
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86112
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