More than a rumor spreads in Parkinson’s disease

As Parkinson’s disease progresses, a massive loss of dopaminergic neurons is accompanied by accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies and Lewy neurites. Inclusions first appear in olfactory bulb and enteric neurons then in ascendant neuroanatomical interconnected...

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Detalles Bibliográficos
Autores principales:	Prymaczok, Natalia Cecilia, Riek, Roland, Gerez, Juan
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Exactas Ciencias Médicas Alpha-synuclein Cell-to-cell propagation Lewy bodies Neurodegeneration Parkinson’s disease Prion-like diseases
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/85895
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-85895
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Ciencias Médicas Alpha-synuclein Cell-to-cell propagation Lewy bodies Neurodegeneration Parkinson’s disease Prion-like diseases
spellingShingle	Ciencias Exactas Ciencias Médicas Alpha-synuclein Cell-to-cell propagation Lewy bodies Neurodegeneration Parkinson’s disease Prion-like diseases Prymaczok, Natalia Cecilia Riek, Roland Gerez, Juan More than a rumor spreads in Parkinson’s disease
topic_facet	Ciencias Exactas Ciencias Médicas Alpha-synuclein Cell-to-cell propagation Lewy bodies Neurodegeneration Parkinson’s disease Prion-like diseases
description	As Parkinson’s disease progresses, a massive loss of dopaminergic neurons is accompanied by accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies and Lewy neurites. Inclusions first appear in olfactory bulb and enteric neurons then in ascendant neuroanatomical interconnected areas, and finally, in late stages of the disease, Lewy bodies are observed in a substantia nigra pars compacta with clear signs of neuronal loss. It is believed that the spreading of Lewy bodies through the nervous system is a consequence of the cell-to-cell propagation of αSyn, that can occur via sequential steps of secretion and uptake. Certain pathological forms of transmitted αSyn are able to seed endogenous counterparts in healthy recipient cells, thus promoting the self-sustained cycle of inclusion formation, amplification and spreading, that ultimately underlies disease progression. Here we review the cell-to-cell propagation of αSyn focusing on its role in the progression of Parkinson’s disease.
format	Articulo Revision
author	Prymaczok, Natalia Cecilia Riek, Roland Gerez, Juan
author_facet	Prymaczok, Natalia Cecilia Riek, Roland Gerez, Juan
author_sort	Prymaczok, Natalia Cecilia
title	More than a rumor spreads in Parkinson’s disease
title_short	More than a rumor spreads in Parkinson’s disease
title_full	More than a rumor spreads in Parkinson’s disease
title_fullStr	More than a rumor spreads in Parkinson’s disease
title_full_unstemmed	More than a rumor spreads in Parkinson’s disease
title_sort	more than a rumor spreads in parkinson’s disease
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/85895
work_keys_str_mv	AT prymaczoknataliacecilia morethanarumorspreadsinparkinsonsdisease AT riekroland morethanarumorspreadsinparkinsonsdisease AT gerezjuan morethanarumorspreadsinparkinsonsdisease
bdutipo_str	Repositorios
_version_	1764820489084076033

More than a rumor spreads in Parkinson’s disease

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