Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different...

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Autores principales:	Bottasso Arias, Natalia María, García, Marina, Bondar, Constanza María, Guzman, Luciana, Redondo, Agustina, Chopita, Néstor Alfredo, Córsico, Betina, Chirdo, Fernando Gabriel
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2015
Materias:	Ciencias Médicas Fatty Acid-Binding Proteins Carrier Proteins Liver fatty
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/85887
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-85887
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Fatty Acid-Binding Proteins Carrier Proteins Liver fatty
spellingShingle	Ciencias Médicas Fatty Acid-Binding Proteins Carrier Proteins Liver fatty Bottasso Arias, Natalia María García, Marina Bondar, Constanza María Guzman, Luciana Redondo, Agustina Chopita, Néstor Alfredo Córsico, Betina Chirdo, Fernando Gabriel Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
topic_facet	Ciencias Médicas Fatty Acid-Binding Proteins Carrier Proteins Liver fatty
description	Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.
format	Articulo Articulo
author	Bottasso Arias, Natalia María García, Marina Bondar, Constanza María Guzman, Luciana Redondo, Agustina Chopita, Néstor Alfredo Córsico, Betina Chirdo, Fernando Gabriel
author_facet	Bottasso Arias, Natalia María García, Marina Bondar, Constanza María Guzman, Luciana Redondo, Agustina Chopita, Néstor Alfredo Córsico, Betina Chirdo, Fernando Gabriel
author_sort	Bottasso Arias, Natalia María
title	Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_short	Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_full	Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_fullStr	Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_full_unstemmed	Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_sort	expression pattern of fatty acid binding proteins in celiac disease enteropathy
publishDate	2015
url	http://sedici.unlp.edu.ar/handle/10915/85887
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Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

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