Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins

The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung...

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Detalles Bibliográficos
Autores principales: Ibáñez, Andrés Esteban, Smaldini, Paola Lorena, Coria, Lorena M., Delpino, María V., Pacífico, Lucila G. G., Oliveira, Sergio C., Risso, Gabriela S., Pasquevich, Karina A., Fossati, Carlos Alberto, Giambartolomei, Guillermo H., Docena, Guillermo Horacio, Cassataro, Juliana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Brucella
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85594
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85594
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Brucella
spellingShingle Ciencias Exactas
Brucella
Ibáñez, Andrés Esteban
Smaldini, Paola Lorena
Coria, Lorena M.
Delpino, María V.
Pacífico, Lucila G. G.
Oliveira, Sergio C.
Risso, Gabriela S.
Pasquevich, Karina A.
Fossati, Carlos Alberto
Giambartolomei, Guillermo H.
Docena, Guillermo Horacio
Cassataro, Juliana
Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
topic_facet Ciencias Exactas
Brucella
description The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow's Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could be used as a broad Th1 mucosal adjuvant for different Ag formulations.
format Articulo
Articulo
author Ibáñez, Andrés Esteban
Smaldini, Paola Lorena
Coria, Lorena M.
Delpino, María V.
Pacífico, Lucila G. G.
Oliveira, Sergio C.
Risso, Gabriela S.
Pasquevich, Karina A.
Fossati, Carlos Alberto
Giambartolomei, Guillermo H.
Docena, Guillermo Horacio
Cassataro, Juliana
author_facet Ibáñez, Andrés Esteban
Smaldini, Paola Lorena
Coria, Lorena M.
Delpino, María V.
Pacífico, Lucila G. G.
Oliveira, Sergio C.
Risso, Gabriela S.
Pasquevich, Karina A.
Fossati, Carlos Alberto
Giambartolomei, Guillermo H.
Docena, Guillermo Horacio
Cassataro, Juliana
author_sort Ibáñez, Andrés Esteban
title Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
title_short Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
title_full Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
title_fullStr Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
title_full_unstemmed Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
title_sort unlipidated outer membrane protein omp16 (u-omp16) from brucella spp. as nasal adjuvant induces a th1 immune response and modulates the th2 allergic response to cow's milk proteins
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85594
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