Allatotropin: an ancestral myotropic neuropeptide involved in feeding

<b>Background:</b> Cell-cell interactions are a basic principle for the organization of tissues and organs allowing them to perform integrated functions and to organize themselves spatially and temporally. Peptidic molecules secreted by neurons and epithelial cells play fundamental roles...

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Autores principales: Alzugaray, María Eugenia, Adami, Mariana Laura, Diambra, Luis Aníbal, Hernandez-Martinez, S., Damborenea, María Cristina, Noriega, F.G., Ronderos, Jorge Rafael
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Biología
Allatotropin
interacción de células
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85506
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85506
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Allatotropin
interacción de células
spellingShingle Biología
Allatotropin
interacción de células
Alzugaray, María Eugenia
Adami, Mariana Laura
Diambra, Luis Aníbal
Hernandez-Martinez, S.
Damborenea, María Cristina
Noriega, F.G.
Ronderos, Jorge Rafael
Allatotropin: an ancestral myotropic neuropeptide involved in feeding
topic_facet Biología
Allatotropin
interacción de células
description <b>Background:</b> Cell-cell interactions are a basic principle for the organization of tissues and organs allowing them to perform integrated functions and to organize themselves spatially and temporally. Peptidic molecules secreted by neurons and epithelial cells play fundamental roles in cell-cell interactions, acting as local neuromodulators, neurohormones, as well as endocrine and paracrine messengers. Allatotropin (AT) is a neuropeptide originally described as a regulator of Juvenile Hormone synthesis, which plays multiple neural, endocrine and myoactive roles in insects and other organisms. <b>Methods:</b> A combination of immunohistochemistry using AT-antibodies and AT-Qdot nanocrystal conjugates was used to identify immunoreactive nerve cells containing the peptide and epithelial-muscular cells targeted by AT in Hydra plagiodesmica. Physiological assays using AT and AT- antibodies revealed that while AT stimulated the extrusion of the hypostome in a dose-response fashion in starved hydroids, the activity of hypostome in hydroids challenged with food was blocked by treatments with different doses of AT-antibodies. <b>Conclusions:</b> AT antibodies immunolabeled nerve cells in the stalk, pedal disc, tentacles and hypostome. AT-Qdot conjugates recognized epithelial-muscular cell in the same tissues, suggesting the existence of anatomical and functional relationships between these two cell populations. Physiological assays indicated that the AT-like peptide is facilitating food ingestion. <b>Significance:</b> Immunochemical, physiological and bioinformatics evidence advocates that AT is an ancestral neuropeptide involved in myoregulatory activities associated with meal ingestion and digestion.
format Articulo
Articulo
author Alzugaray, María Eugenia
Adami, Mariana Laura
Diambra, Luis Aníbal
Hernandez-Martinez, S.
Damborenea, María Cristina
Noriega, F.G.
Ronderos, Jorge Rafael
author_facet Alzugaray, María Eugenia
Adami, Mariana Laura
Diambra, Luis Aníbal
Hernandez-Martinez, S.
Damborenea, María Cristina
Noriega, F.G.
Ronderos, Jorge Rafael
author_sort Alzugaray, María Eugenia
title Allatotropin: an ancestral myotropic neuropeptide involved in feeding
title_short Allatotropin: an ancestral myotropic neuropeptide involved in feeding
title_full Allatotropin: an ancestral myotropic neuropeptide involved in feeding
title_fullStr Allatotropin: an ancestral myotropic neuropeptide involved in feeding
title_full_unstemmed Allatotropin: an ancestral myotropic neuropeptide involved in feeding
title_sort allatotropin: an ancestral myotropic neuropeptide involved in feeding
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85506
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