A BK (Slo1) channel journey from molecule to physiology

Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca<SUP>2+</SUP> and membrane voltage, BK channels provide a damping mechanism for excitatory signa...

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Autores principales: Contreras, Gustavo F., Castillo, Karen, Enrique, Nicolás Jorge, Carrasquel Ursulaez, Willy, Castillo, Juan Pablo, Milesi, Verónica, Neely, Alan, Alvarez, Osvaldo, Ferreira, Gonzalo, Gonzalez, Carlos, Latorre, Ramón
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Auxiliary subunits
BK channels
Diseases
Slo1
Smooth muscle
Voltage sensor
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85241
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85241
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Auxiliary subunits
BK channels
Diseases
Slo1
Smooth muscle
Voltage sensor
spellingShingle Ciencias Exactas
Auxiliary subunits
BK channels
Diseases
Slo1
Smooth muscle
Voltage sensor
Contreras, Gustavo F.
Castillo, Karen
Enrique, Nicolás Jorge
Carrasquel Ursulaez, Willy
Castillo, Juan Pablo
Milesi, Verónica
Neely, Alan
Alvarez, Osvaldo
Ferreira, Gonzalo
Gonzalez, Carlos
Latorre, Ramón
A BK (Slo1) channel journey from molecule to physiology
topic_facet Ciencias Exactas
Auxiliary subunits
BK channels
Diseases
Slo1
Smooth muscle
Voltage sensor
description Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca<SUP>2+</SUP> and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel ́ subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca<SUP>2+</SUP> sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has been found to be relevant in many physiological processes. This review includes the hallmarks of BK channel biophysics and its physiological impact on specific cells and tissues, highlighting its relationship with auxiliary subunit expression.
format Articulo
Revision
author Contreras, Gustavo F.
Castillo, Karen
Enrique, Nicolás Jorge
Carrasquel Ursulaez, Willy
Castillo, Juan Pablo
Milesi, Verónica
Neely, Alan
Alvarez, Osvaldo
Ferreira, Gonzalo
Gonzalez, Carlos
Latorre, Ramón
author_facet Contreras, Gustavo F.
Castillo, Karen
Enrique, Nicolás Jorge
Carrasquel Ursulaez, Willy
Castillo, Juan Pablo
Milesi, Verónica
Neely, Alan
Alvarez, Osvaldo
Ferreira, Gonzalo
Gonzalez, Carlos
Latorre, Ramón
author_sort Contreras, Gustavo F.
title A BK (Slo1) channel journey from molecule to physiology
title_short A BK (Slo1) channel journey from molecule to physiology
title_full A BK (Slo1) channel journey from molecule to physiology
title_fullStr A BK (Slo1) channel journey from molecule to physiology
title_full_unstemmed A BK (Slo1) channel journey from molecule to physiology
title_sort bk (slo1) channel journey from molecule to physiology
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85241
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