Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids

The fluoroquinolone antimicrobial drug danofloxacin was administered to sheep intravenously (i.v.) and intramuscularly (i.m.) at a dose of 1.25 mg/kg of body weight in a two-period crossover study. The pharmacokinetic properties of danofloxacin in serum, inflamed tissue cage fluid (exudate), and non...

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Autores principales: Aliabadi, F. Shojaee, Landoni, María Fabiana, Lees, P.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Ciencias Veterinarias
Farmacocinética
Fármacodinamia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84677
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84677
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Farmacocinética
Fármacodinamia
spellingShingle Ciencias Veterinarias
Farmacocinética
Fármacodinamia
Aliabadi, F. Shojaee
Landoni, María Fabiana
Lees, P.
Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
topic_facet Ciencias Veterinarias
Farmacocinética
Fármacodinamia
description The fluoroquinolone antimicrobial drug danofloxacin was administered to sheep intravenously (i.v.) and intramuscularly (i.m.) at a dose of 1.25 mg/kg of body weight in a two-period crossover study. The pharmacokinetic properties of danofloxacin in serum, inflamed tissue cage fluid (exudate), and noninflamed tissue cage fluid (transudate) were established by using a tissue cage model. The in vitro and ex vivo activities of danofloxacin in serum, exudate, and transudate against a pathogenic strain of Mannheimia haemolytica were established. Integration of in vivo pharmacokinetic data with the in vitro MIC provided mean values for the area under the curve (AUC)/MIC for serum, exudate, and transudate of 60.5, 85.6, and 45.7 h, respectively, after i.v. dosing and 55.9, 77.9, and 49.1 h, respectively, after i.m. dosing. After i.m. dosing, the maximum concentration/MIC ratios for serum, exudate, and transudate were 10.8, 3.0, and 1.6, respectively. The ex vivo growth inhibition data after i.m. dosing were fitted to the inhibitory sigmoid Emax equation to provide the values of AUC/MIC required to produce bacteriostasis, bactericidal activity, and elimination of bacteria. The respective values for serum were 17.8, 20.2, and 28.7 h, and slightly higher values were obtained for transudate and exudate. It is proposed that use of these data might provide a novel approach to the rational design of dosage schedules.
format Articulo
Articulo
author Aliabadi, F. Shojaee
Landoni, María Fabiana
Lees, P.
author_facet Aliabadi, F. Shojaee
Landoni, María Fabiana
Lees, P.
author_sort Aliabadi, F. Shojaee
title Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
title_short Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
title_full Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
title_fullStr Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
title_full_unstemmed Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
title_sort pharmacokinetics (pk), pharmacodynamics (pd), and pk-pd integration of danofloxacin in sheep biological fluids
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/84677
work_keys_str_mv AT aliabadifshojaee pharmacokineticspkpharmacodynamicspdandpkpdintegrationofdanofloxacininsheepbiologicalfluids
AT landonimariafabiana pharmacokineticspkpharmacodynamicspdandpkpdintegrationofdanofloxacininsheepbiologicalfluids
AT leesp pharmacokineticspkpharmacodynamicspdandpkpdintegrationofdanofloxacininsheepbiologicalfluids
bdutipo_str Repositorios
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