Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart

The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength after which occurs a slow force increase (SFR) that takes several minutes to fully develop. The SFR was detected in a wide variety of experimental preparations including isolated myocytes, papillary...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Cingolani, Horacio Eugenio, Pérez, Néstor Gustavo, Pieske, Burket, Lewinski, Dirk von, Camilión de Hurtado, María Cristina
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2003
Materias:
Ciencias Médicas
Angiotensin
Endothelins
Na/Ca-exchanger
Na/H-exchanger
Stretch/m-e coupling
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84584
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84584
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Angiotensin
Endothelins
Na/Ca-exchanger
Na/H-exchanger
Stretch/m-e coupling
spellingShingle Ciencias Médicas
Angiotensin
Endothelins
Na/Ca-exchanger
Na/H-exchanger
Stretch/m-e coupling
Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Pieske, Burket
Lewinski, Dirk von
Camilión de Hurtado, María Cristina
Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart
topic_facet Ciencias Médicas
Angiotensin
Endothelins
Na/Ca-exchanger
Na/H-exchanger
Stretch/m-e coupling
description The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength after which occurs a slow force increase (SFR) that takes several minutes to fully develop. The SFR was detected in a wide variety of experimental preparations including isolated myocytes, papillary muscles and/or trabeculae, left ventricle strips of failing human myocardium, in vitro isovolumic and in vivo volume-loaded hearts. It was established that the initial increase in force is due to an increase in myofilament Ca<SUP>2+</SUP> responsiveness, whereas the SFR results from an increase in the Ca<SUP>2+</SUP> transient. However, the mechanism(s) for this increase in the Ca<SUP>2+</SUP> transient has remained undefined until the proposal of Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) activation by stretch. Studies in multicellular cardiac muscle preparations from cat, rabbit, rat and failing human heart have shown evidence that the stretch induces a rise in intracellular Na<SUP>+</SUP> ([Na<SUP>+</SUP>]<SUB>i</SUB>) through NHE activation, which subsequently leads to an increase in Ca<SUP>2+</SUP> transient via reverse-mode Na<SUP>+</SUP>/Ca<SUP>2+</SUP> (NCX) exchange. These experimental data agree with a theoretical ionic model of cardiomyocytes that predicted an increased Na<SUP>+</SUP> influx and a concurrent increase in Ca<SUP>2+</SUP> entry through NCX as the cause of the SFR to muscle stretch. However, there are aspects that await definitive demonstration, and perhaps subjected to species-related differences like the possibility of an autocrine/paracrine loop involving angiotensin II and endothelin as the underlying mechanism for stretch-induced NHE activation leading to the rise in [Na<SUP>+</SUP>]<SUB>i</SUB> and reverse-mode NCX.
format Articulo
Revision
author Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Pieske, Burket
Lewinski, Dirk von
Camilión de Hurtado, María Cristina
author_facet Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Pieske, Burket
Lewinski, Dirk von
Camilión de Hurtado, María Cristina
author_sort Cingolani, Horacio Eugenio
title Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart
title_short Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart
title_full Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart
title_fullStr Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart
title_full_unstemmed Stretch-elicited Na+/H+ exchanger activation: The autocrine/paracrine loop and its mechanical counterpart
title_sort stretch-elicited na+/h+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/84584
work_keys_str_mv AT cingolanihoracioeugenio stretchelicitednahexchangeractivationtheautocrineparacrineloopanditsmechanicalcounterpart
AT pereznestorgustavo stretchelicitednahexchangeractivationtheautocrineparacrineloopanditsmechanicalcounterpart
AT pieskeburket stretchelicitednahexchangeractivationtheautocrineparacrineloopanditsmechanicalcounterpart
AT lewinskidirkvon stretchelicitednahexchangeractivationtheautocrineparacrineloopanditsmechanicalcounterpart
AT camiliondehurtadomariacristina stretchelicitednahexchangeractivationtheautocrineparacrineloopanditsmechanicalcounterpart
bdutipo_str Repositorios
_version_ 1764820488936226817

Ejemplares similares