Thymulin-based gene therapy and pituitary function in animal models of aging

Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the 1970s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information,...

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Detalles Bibliográficos
Autores principales:	Reggiani, Paula Cecilia, Poch, Brenda, Cónsole-Avegliano, Gloria Miriam, Rimoldi, Omar Jorge, Schwerdt, José Ignacio, Tüngler, Victoria, García de Bravo, Margarita María, Dardenne, Mireille, Goya, Rodolfo Gustavo
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Bioquímica Anti-inflammatory properties Gene therapy Hypophysiotropic activity Neuroendocrine control Ovarian dysgenesis Regulatable adenovectors Thymulin
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/84557
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-84557
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Bioquímica Anti-inflammatory properties Gene therapy Hypophysiotropic activity Neuroendocrine control Ovarian dysgenesis Regulatable adenovectors Thymulin
spellingShingle	Bioquímica Anti-inflammatory properties Gene therapy Hypophysiotropic activity Neuroendocrine control Ovarian dysgenesis Regulatable adenovectors Thymulin Reggiani, Paula Cecilia Poch, Brenda Cónsole-Avegliano, Gloria Miriam Rimoldi, Omar Jorge Schwerdt, José Ignacio Tüngler, Victoria García de Bravo, Margarita María Dardenne, Mireille Goya, Rodolfo Gustavo Thymulin-based gene therapy and pituitary function in animal models of aging
topic_facet	Bioquímica Anti-inflammatory properties Gene therapy Hypophysiotropic activity Neuroendocrine control Ovarian dysgenesis Regulatable adenovectors Thymulin
description	Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the 1970s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, thymulin was shown to possess anti-inflammatory and analgesic properties in the brain. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. These include bidirectional regulatable Tet-Off vector systems that simultaneously express metFTS and green fluorescent protein and that can be downregulated reversibly by the addition of the antibiotic doxycycline. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, taken as a suitable model of neuroendocrine and reproductive aging. The present article briefly reviews the literature on the physiology of the thymulin-pituitary axis as well as on the new molecular tools available to exploit the therapeutic potential of thymulin.
format	Articulo Articulo
author	Reggiani, Paula Cecilia Poch, Brenda Cónsole-Avegliano, Gloria Miriam Rimoldi, Omar Jorge Schwerdt, José Ignacio Tüngler, Victoria García de Bravo, Margarita María Dardenne, Mireille Goya, Rodolfo Gustavo
author_facet	Reggiani, Paula Cecilia Poch, Brenda Cónsole-Avegliano, Gloria Miriam Rimoldi, Omar Jorge Schwerdt, José Ignacio Tüngler, Victoria García de Bravo, Margarita María Dardenne, Mireille Goya, Rodolfo Gustavo
author_sort	Reggiani, Paula Cecilia
title	Thymulin-based gene therapy and pituitary function in animal models of aging
title_short	Thymulin-based gene therapy and pituitary function in animal models of aging
title_full	Thymulin-based gene therapy and pituitary function in animal models of aging
title_fullStr	Thymulin-based gene therapy and pituitary function in animal models of aging
title_full_unstemmed	Thymulin-based gene therapy and pituitary function in animal models of aging
title_sort	thymulin-based gene therapy and pituitary function in animal models of aging
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/84557
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bdutipo_str	Repositorios
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Thymulin-based gene therapy and pituitary function in animal models of aging

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