Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats

The objective of this study was to compare the pharmacokinetic characteristics of ascaridole following oral administration of pure ascaridole and Jinghuaweikang (JHWK) capsule. Besides, additional rats were given pure ascaridole via intravenous administration for the bioavailability study. The conce...

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Detalles Bibliográficos
Autores principales: Zhang, Boli, Zhou, Shuiping, Ma, Xiaohui, Wang, Xiangyang, Li, Wei, Chu, Yang, Zhu, Yonghong
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacocinética
Chenopodium ambrosioides
Monoterpenos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8448
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_2_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8448
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacocinética
Chenopodium ambrosioides
Monoterpenos
spellingShingle Farmacia
Farmacocinética
Chenopodium ambrosioides
Monoterpenos
Zhang, Boli
Zhou, Shuiping
Ma, Xiaohui
Wang, Xiangyang
Li, Wei
Chu, Yang
Zhu, Yonghong
Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats
topic_facet Farmacia
Farmacocinética
Chenopodium ambrosioides
Monoterpenos
description The objective of this study was to compare the pharmacokinetic characteristics of ascaridole following oral administration of pure ascaridole and Jinghuaweikang (JHWK) capsule. Besides, additional rats were given pure ascaridole via intravenous administration for the bioavailability study. The concentration of ascaridole in rat plasma was determined by a GC/MS method. Following oral administration of pure ascaridole and JHWK capsule, the maximum mean concentration in rat plasma (Cmax, 2701.4 ± 1282.6 ng/mL and 3008.0 ± 273.5 ng/mL) were achieved at 0.25 ± 0.09 h and 0.47 ± 0.22 h (Tmax), and the absolute bioavailabilities were approximately 20.8 and 26.9 %, respectively. The results indicated that other ingredients in JHWK capsule might facilitate and prolong the absorption procedure of ascaridole, and thus enhance its bioavailability in rats. The present study provided the necessary information for the further investigation of Chenopodium ambrosioides L. and its preparation.
format Articulo
Comunicacion
author Zhang, Boli
Zhou, Shuiping
Ma, Xiaohui
Wang, Xiangyang
Li, Wei
Chu, Yang
Zhu, Yonghong
author_facet Zhang, Boli
Zhou, Shuiping
Ma, Xiaohui
Wang, Xiangyang
Li, Wei
Chu, Yang
Zhu, Yonghong
author_sort Zhang, Boli
title Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats
title_short Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats
title_full Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats
title_fullStr Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats
title_full_unstemmed Comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and Jinghuaweikang capsule to rats
title_sort comparative pharmacokinetic study of ascaridole after oral administration of ascaridole and jinghuaweikang capsule to rats
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8448
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_2_7.pdf
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