Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death

Glioblastoma is one of the most malignant brain tumors. Current treatments for glioblastoma usually make poor responses, and novel treatment strategies are extremely imperative. Cytochalasin E was reported to inhibit angiogenesis and tumor growth in some studies, but its effects on gliomas are still...

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Autores principales: Xing, Biao, Zhang, Guofeng, Li, Meng, Hu, Weixing, Gu, Peiyuan, Wei, Dong, Xu, Jing, Ma, Banyou, Gu, Bing, Chen, Gong, Li, Junyang
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Actinas
Glioma
Citocalasinas
Apoptosis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8442
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_2_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8442
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Actinas
Glioma
Citocalasinas
Apoptosis
spellingShingle Farmacia
Actinas
Glioma
Citocalasinas
Apoptosis
Xing, Biao
Zhang, Guofeng
Li, Meng
Hu, Weixing
Gu, Peiyuan
Wei, Dong
Xu, Jing
Ma, Banyou
Gu, Bing
Chen, Gong
Li, Junyang
Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death
topic_facet Farmacia
Actinas
Glioma
Citocalasinas
Apoptosis
description Glioblastoma is one of the most malignant brain tumors. Current treatments for glioblastoma usually make poor responses, and novel treatment strategies are extremely imperative. Cytochalasin E was reported to inhibit angiogenesis and tumor growth in some studies, but its effects on gliomas are still unknown. In this study, we found cytochalasin E inhibits U87 human glioblastoma cell growth in a very low concentration range of 10<sup>-8</sup> to 10<sup>-6</sup> M in a time and concentration dependent manner, and the IC50 were 1.17 ± 0.32 × 10<sup>-7</sup> M for 48 h treatment, 6.65 ± 1.12 × 10<sup>-8</sup> M for 72 h and 3.78 ± 1.30 × 10<sup>-8</sup> M for 96 h. We also found cytochalasin E induces cell-cycle G2/M phase arrest (72 h-treatment of 10<sup>-6</sup> M cytochalasin E caused 56.2 ± 6.1 % cells arrest in G2/M phase) and cell apoptosis (96 h-treatment of 10<sup>-6</sup> M cytochalasin E induced 24.1 ± 4.2 % cells apoptosis). Thus, cytochalasin E is proposed as a potential agent for glioblastoma chemotherapy.
format Articulo
Comunicacion
author Xing, Biao
Zhang, Guofeng
Li, Meng
Hu, Weixing
Gu, Peiyuan
Wei, Dong
Xu, Jing
Ma, Banyou
Gu, Bing
Chen, Gong
Li, Junyang
author_facet Xing, Biao
Zhang, Guofeng
Li, Meng
Hu, Weixing
Gu, Peiyuan
Wei, Dong
Xu, Jing
Ma, Banyou
Gu, Bing
Chen, Gong
Li, Junyang
author_sort Xing, Biao
title Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death
title_short Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death
title_full Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death
title_fullStr Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death
title_full_unstemmed Cytochalasin E, a potential agent for anti-glioma therapy, efficiently induces U87 human glioblastoma cell death
title_sort cytochalasin e, a potential agent for anti-glioma therapy, efficiently induces u87 human glioblastoma cell death
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8442
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_2_1.pdf
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