Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic

Blood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the cou...

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Autores principales: Bunikis, Jonas, Tsao, Jean, Luke, Catherine J., Luna, María Gabriela, Fish, Durland, Barbour, Alan G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2004
Materias:
Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84414
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84414
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
spellingShingle Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
Bunikis, Jonas
Tsao, Jean
Luke, Catherine J.
Luna, María Gabriela
Fish, Durland
Barbour, Alan G.
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
topic_facet Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
description Blood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks.
format Articulo
Articulo
author Bunikis, Jonas
Tsao, Jean
Luke, Catherine J.
Luna, María Gabriela
Fish, Durland
Barbour, Alan G.
author_facet Bunikis, Jonas
Tsao, Jean
Luke, Catherine J.
Luna, María Gabriela
Fish, Durland
Barbour, Alan G.
author_sort Bunikis, Jonas
title Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_short Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_full Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_fullStr Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_full_unstemmed Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_sort borrelia burgdorferi infection in a natural population of peromyscus leucopus mice: a longitudinal study in an area where lyme borreliosis is highly endemic
publishDate 2004
url http://sedici.unlp.edu.ar/handle/10915/84414
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