Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads

The objective of the present investigation was to evaluate the potential of gellan gum- low molecular weight chitosan (GG-LMCH) polyelectrolyte complex (PEC) in the form of beads as prolonged release stomach specific floating drug delivery system. PEC beads were prepared in one step, without using a...

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Autores principales: Pandit, Jayant K., Sharma, Suresh D., Nagarwal, Ramesh C., Verma, Anurag
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Quitosana
buoyancy; drug release; encapsulation efficiency; gellan gum; low molecular weight chitosan; polyelectrolyte complex; rifabutin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8441
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_21.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8441
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Quitosana
buoyancy; drug release; encapsulation efficiency; gellan gum; low molecular weight chitosan; polyelectrolyte complex; rifabutin
spellingShingle Farmacia
Quitosana
buoyancy; drug release; encapsulation efficiency; gellan gum; low molecular weight chitosan; polyelectrolyte complex; rifabutin
Pandit, Jayant K.
Sharma, Suresh D.
Nagarwal, Ramesh C.
Verma, Anurag
Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
topic_facet Farmacia
Quitosana
buoyancy; drug release; encapsulation efficiency; gellan gum; low molecular weight chitosan; polyelectrolyte complex; rifabutin
description The objective of the present investigation was to evaluate the potential of gellan gum- low molecular weight chitosan (GG-LMCH) polyelectrolyte complex (PEC) in the form of beads as prolonged release stomach specific floating drug delivery system. PEC beads were prepared in one step, without using any chemical crosslinker, by dropwise addition of GG to a solution of LMCH in acetic acid. Buoyancy to the beads was attributed to the use of CaCO<sub>3</sub> . The % buoyancy, encapsulation efficiency and drug release from PEC beads were compared with Ca<sup>++</sup> crosslinked GG floating beads prepared under same conditions using rifabutin as model drug. Our finding showed that the PEC beads remained buoyant for up to 8 h and showed significantly better (p < 0.05) control over drug release compared to Ca<sup>++</sup> crosslinked GG beads and, therefore, possess great potential for the stomach specific sustained delivery of drugs like rifabutin for the treatment of Helicobacter pylori infection.
format Articulo
Articulo
author Pandit, Jayant K.
Sharma, Suresh D.
Nagarwal, Ramesh C.
Verma, Anurag
author_facet Pandit, Jayant K.
Sharma, Suresh D.
Nagarwal, Ramesh C.
Verma, Anurag
author_sort Pandit, Jayant K.
title Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
title_short Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
title_full Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
title_fullStr Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
title_full_unstemmed Preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
title_sort preparation and characterization of floating gellan-chitosan polyelectrolyte complex beads
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8441
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_21.pdf
work_keys_str_mv AT panditjayantk preparationandcharacterizationoffloatinggellanchitosanpolyelectrolytecomplexbeads
AT sharmasureshd preparationandcharacterizationoffloatinggellanchitosanpolyelectrolytecomplexbeads
AT nagarwalrameshc preparationandcharacterizationoffloatinggellanchitosanpolyelectrolytecomplexbeads
AT vermaanurag preparationandcharacterizationoffloatinggellanchitosanpolyelectrolytecomplexbeads
bdutipo_str Repositorios
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