Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis

The purpose of this work was to design and evaluate a novel vaginal delivery system for the local treatment of vaginal candidiasis. Bioadhesive vaginal films of metronidazole that could be retained in the vagina for prolonged period for more effective treatment against vaginal candidiasis were formu...

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Detalles Bibliográficos
Autores principales: Younus Pasha, Mohammed, Bhat, Sudeendra R., Hani, Umme
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Candidiasis Vulvovaginal
Metronidazol
Quitosana
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8433
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_13.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8433
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Candidiasis Vulvovaginal
Metronidazol
Quitosana
spellingShingle Farmacia
Candidiasis Vulvovaginal
Metronidazol
Quitosana
Younus Pasha, Mohammed
Bhat, Sudeendra R.
Hani, Umme
Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
topic_facet Farmacia
Candidiasis Vulvovaginal
Metronidazol
Quitosana
description The purpose of this work was to design and evaluate a novel vaginal delivery system for the local treatment of vaginal candidiasis. Bioadhesive vaginal films of metronidazole that could be retained in the vagina for prolonged period for more effective treatment against vaginal candidiasis were formulated by solvent casting technique using bioadhesive polymers such as chitosan, HPC and sodium CMC. Glycerine and propylene glycol were used as plasticizer. The films were characterized for various physical, mechanical, and aesthetic properties. Bioadhesive strength and in vitro release studies suggested that the prolonged release bioadhesive vaginal film formulation of metronidazole is useful and effective dosage form for treating vaginal candidiasis. It may be concluded from present study that MTZ bioadhesive vaginal film can be used as a novel delivery system for local therapy of vaginal candidiasis.
format Articulo
Articulo
author Younus Pasha, Mohammed
Bhat, Sudeendra R.
Hani, Umme
author_facet Younus Pasha, Mohammed
Bhat, Sudeendra R.
Hani, Umme
author_sort Younus Pasha, Mohammed
title Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
title_short Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
title_full Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
title_fullStr Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
title_full_unstemmed Formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
title_sort formulation design and evaluation of bioadhesive vaginal films of metronidazole for vaginal candidiasis
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8433
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_13.pdf
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bdutipo_str Repositorios
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