Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets

The present study was undertaken to investigate the effect of nature of polymers like HPMC, carbopol-934P and their content levels on the release profiles of water soluble drug, diclofenac potassium. For this purpose, different tablets were prepared by wet granulation technique using HPMC-K15, carbo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Hussain, Izhar, Azhar, Saira, Murtaza, Ghulam, Ullah, Majeed
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Polímeros
Sistemas de Liberación de Medicamentos
Diclofenaco
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8432
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8432
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Polímeros
Sistemas de Liberación de Medicamentos
Diclofenaco
spellingShingle Farmacia
Polímeros
Sistemas de Liberación de Medicamentos
Diclofenaco
Hussain, Izhar
Azhar, Saira
Murtaza, Ghulam
Ullah, Majeed
Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
topic_facet Farmacia
Polímeros
Sistemas de Liberación de Medicamentos
Diclofenaco
description The present study was undertaken to investigate the effect of nature of polymers like HPMC, carbopol-934P and their content levels on the release profiles of water soluble drug, diclofenac potassium. For this purpose, different tablets were prepared by wet granulation technique using HPMC-K15, carbopol-934P and blends of HPMC with carbopol-934P. Release kinetics was evaluated using USP apparatus II at 50 rpm in phosphate buffer pH 6.8 for 12 h. HPMC showed less release retardant effect compared to carbopol-934P at same concentration, while blends of these polymers gave an intermediate release profile, i.e. decreasing the quantity of carbopol-934P while increasing the amount of HPMC, increased the release of drug from matrix tablets. The release retarding capacity of two used polymers is as follows: Carbopol- 934P > HPMC-K15. Formulations containing HPMC exhibited first order release, while all other formulations showed zero order pattern. Present study showed that drug release retardant effect of carbopol was higher as compared to HPMC. It also confirmed that release rate of drug is mainly controlled by drugpolymer ratios.
format Articulo
Articulo
author Hussain, Izhar
Azhar, Saira
Murtaza, Ghulam
Ullah, Majeed
author_facet Hussain, Izhar
Azhar, Saira
Murtaza, Ghulam
Ullah, Majeed
author_sort Hussain, Izhar
title Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
title_short Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
title_full Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
title_fullStr Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
title_full_unstemmed Study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
title_sort study of drug release retardant capability of hydroxypropylmethylcellulose and carbopol in matrix tablets
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8432
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_12.pdf
work_keys_str_mv AT hussainizhar studyofdrugreleaseretardantcapabilityofhydroxypropylmethylcelluloseandcarbopolinmatrixtablets
AT azharsaira studyofdrugreleaseretardantcapabilityofhydroxypropylmethylcelluloseandcarbopolinmatrixtablets
AT murtazaghulam studyofdrugreleaseretardantcapabilityofhydroxypropylmethylcelluloseandcarbopolinmatrixtablets
AT ullahmajeed studyofdrugreleaseretardantcapabilityofhydroxypropylmethylcelluloseandcarbopolinmatrixtablets
bdutipo_str Repositorios
_version_ 1764820488598585348

Ejemplares similares