Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug
The aim of this study was to investigate the potential of a polyethylene glycol-phosphatidylethanolamine conjugate (PEG<sub>2000</sub> -DSPE) to solubilize budesonide (BUD) for pulmonary delivery. The BUD-strictly stabilized phospholipid nanomicelles (SSMs) were prepared using the coprec...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8431 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_11.pdf |
| Aporte de: |
| id |
I19-R120-10915-8431 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Micelas nebulizer; pharmacodynamic; pulmonary delivery Budesonida |
| spellingShingle |
Farmacia Micelas nebulizer; pharmacodynamic; pulmonary delivery Budesonida Tan, Yvonne T.F. Abdulameer, Shaymaa A. Peh, Kok K. Darwis, Yusrida Sahib, Mohanad N. Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| topic_facet |
Farmacia Micelas nebulizer; pharmacodynamic; pulmonary delivery Budesonida |
| description |
The aim of this study was to investigate the potential of a polyethylene glycol-phosphatidylethanolamine conjugate (PEG<sub>2000</sub> -DSPE) to solubilize budesonide (BUD) for pulmonary delivery. The BUD-strictly stabilized phospholipid nanomicelles (SSMs) were prepared using the coprecipitation and reconstitution method and the physicochemical characteristics and pharmacodynamic duration of the BUD-SSMs were determined. The solubility of BUD was highly improved by at least 52 times its intrinsic solubility. The hydrodynamic particle size and zeta potential were 14.31 ± 1.40 nm and -46.61 ± 2.94 mV, respectively. The in vitro release of BUD from SSMs was completed within 6 days. Aerosolization of rehydrated BUD-SSMs with different nebulizers showed superior and significant aerodynamic characterizations compared to Pulmicort Respules® (PR). An in vivo study showed a significant reduction in the inflammatory cell counts of bronchoalveolar lavage fluid compared to PR. As a result, this study suggested that PEG<sub>2000</sub> -DSPE is a promising candidate as a budesonide carrier for pulmonary delivery. |
| format |
Articulo Articulo |
| author |
Tan, Yvonne T.F. Abdulameer, Shaymaa A. Peh, Kok K. Darwis, Yusrida Sahib, Mohanad N. |
| author_facet |
Tan, Yvonne T.F. Abdulameer, Shaymaa A. Peh, Kok K. Darwis, Yusrida Sahib, Mohanad N. |
| author_sort |
Tan, Yvonne T.F. |
| title |
Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| title_short |
Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| title_full |
Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| title_fullStr |
Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| title_full_unstemmed |
Polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| title_sort |
polyethylene glycol-phosphatidylethanolamine conjugate as a pulmonary nanocarrier for poorly soluble drug |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8431 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_11.pdf |
| work_keys_str_mv |
AT tanyvonnetf polyethyleneglycolphosphatidylethanolamineconjugateasapulmonarynanocarrierforpoorlysolubledrug AT abdulameershaymaaa polyethyleneglycolphosphatidylethanolamineconjugateasapulmonarynanocarrierforpoorlysolubledrug AT pehkokk polyethyleneglycolphosphatidylethanolamineconjugateasapulmonarynanocarrierforpoorlysolubledrug AT darwisyusrida polyethyleneglycolphosphatidylethanolamineconjugateasapulmonarynanocarrierforpoorlysolubledrug AT sahibmohanadn polyethyleneglycolphosphatidylethanolamineconjugateasapulmonarynanocarrierforpoorlysolubledrug |
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Repositorios |
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1764820488589148164 |