Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were p...
Guardado en:
Autores principales: | , , , , |
---|---|
Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2012
|
Materias: | |
Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8426 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_6.pdf |
Aporte de: |
id |
I19-R120-10915-8426 |
---|---|
record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos |
spellingShingle |
Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos Pandit, Jayant K. Verma, Navneet Mishra, Arun K. Verma, Anurag Dixit, Raghav Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
topic_facet |
Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos |
description |
The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were prepared in one step without using any chemical crosslinker. Briefly, an emulsion of gellan gum (GG) with gelucire 39/01 and 50/13 containing CaCO<sub>3</sub> and drug was extruded dropwise into low molecular weight chitosan (LMCH) solution. Beads formed instantaneously were cured for 15 min at elevated temperature (37 °C). Prepared beads showed excellent buoyancy along with significantly improved encapsulation efficiency and sustained release of metronidazole when compared to floating gellan-chitosan PEC beads prepared in the similar manner but without gelucires. Experimental data obtained from the present investigation showed that floating emulsion PEC beads may form a potential stomach site specific drug delivery system for the delivery of highly water soluble drugs with an absorption window in the upper gastrointestinal tract. |
format |
Articulo Articulo |
author |
Pandit, Jayant K. Verma, Navneet Mishra, Arun K. Verma, Anurag Dixit, Raghav |
author_facet |
Pandit, Jayant K. Verma, Navneet Mishra, Arun K. Verma, Anurag Dixit, Raghav |
author_sort |
Pandit, Jayant K. |
title |
Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
title_short |
Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
title_full |
Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
title_fullStr |
Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
title_full_unstemmed |
Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
title_sort |
floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release |
publishDate |
2012 |
url |
http://sedici.unlp.edu.ar/handle/10915/8426 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_6.pdf |
work_keys_str_mv |
AT panditjayantk floatinggellanchitosanpolyelectrolytecomplexbeadseffectofgeluciresincorporationonencapsulationefficiencyanddrugrelease AT vermanavneet floatinggellanchitosanpolyelectrolytecomplexbeadseffectofgeluciresincorporationonencapsulationefficiencyanddrugrelease AT mishraarunk floatinggellanchitosanpolyelectrolytecomplexbeadseffectofgeluciresincorporationonencapsulationefficiencyanddrugrelease AT vermaanurag floatinggellanchitosanpolyelectrolytecomplexbeadseffectofgeluciresincorporationonencapsulationefficiencyanddrugrelease AT dixitraghav floatinggellanchitosanpolyelectrolytecomplexbeadseffectofgeluciresincorporationonencapsulationefficiencyanddrugrelease |
bdutipo_str |
Repositorios |
_version_ |
1764820488537767940 |