In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case
In order to develop an approach to evaluate the preabsorptive behavior of supramolecular aggregate carriers, three commercial oral formulations of a mixture of lipophilic and hydrophilic vitamins dispersed in water-glycerin-polysorbate-80 (PS-80) vehicle were subjected to dynamic light scattering an...
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| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8425 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_5.pdf |
| Aporte de: |
| id |
I19-R120-10915-8425 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Difusión dynamic light scattering; in vitro test; oral multivitamins; preabsortive events; supramolecular aggregates Vitaminas In Vitro |
| spellingShingle |
Farmacia Difusión dynamic light scattering; in vitro test; oral multivitamins; preabsortive events; supramolecular aggregates Vitaminas In Vitro Manzo, Rubén H. Jiménez Kairuz, Álvaro Palena, María C. In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case |
| topic_facet |
Farmacia Difusión dynamic light scattering; in vitro test; oral multivitamins; preabsortive events; supramolecular aggregates Vitaminas In Vitro |
| description |
In order to develop an approach to evaluate the preabsorptive behavior of supramolecular aggregate carriers, three commercial oral formulations of a mixture of lipophilic and hydrophilic vitamins dispersed in water-glycerin-polysorbate-80 (PS-80) vehicle were subjected to dynamic light scattering and electrokinetic determinations. They exhibited diffusion coefficients ranging from 4.46 .10<sup>-9</sup> to 3.22 .10<sup>-8</sup> cm<sup>2</sup>/s. To mimic in vivo environment the formulations were progressively diluted with water and simulated gastric and intestinal fluids until a ratio 1:10. Hydrodynamic diameters (d<sub>H</sub>) at 37 °C and electrokinetic potentials of each formulation remained almost unchanged in the three assayed conditions. However, the average d<sub>H</sub> were 1.00, 1.36 and 1.63 times higher than a reference dispersion of PS-80 revealing significant differences among formulations. Concentration of PS-80 in diluted samples is about 10<sup>3</sup> times above its critical micellar concentration. Therefore, loaded core/shell micelles appears to be robust drug carriers that will interact with the gastrointestinal membranes upon administration. The observed differences in size and/or shape would be related to the biopharmaceutical performance of multisource products. Besides, the developed approach could be used in developing and control stages of such pharmaceutical systems. |
| format |
Articulo Articulo |
| author |
Manzo, Rubén H. Jiménez Kairuz, Álvaro Palena, María C. |
| author_facet |
Manzo, Rubén H. Jiménez Kairuz, Álvaro Palena, María C. |
| author_sort |
Manzo, Rubén H. |
| title |
In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case |
| title_short |
In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case |
| title_full |
In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case |
| title_fullStr |
In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case |
| title_full_unstemmed |
In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : Oral multivitamins as a model case |
| title_sort |
in vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering : oral multivitamins as a model case |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8425 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_5.pdf |
| work_keys_str_mv |
AT manzorubenh invitroevaluationofpreabsorptiveeventsofdispersedsupramolecularaggregatesbydynamiclightscatteringoralmultivitaminsasamodelcase AT jimenezkairuzalvaro invitroevaluationofpreabsorptiveeventsofdispersedsupramolecularaggregatesbydynamiclightscatteringoralmultivitaminsasamodelcase AT palenamariac invitroevaluationofpreabsorptiveeventsofdispersedsupramolecularaggregatesbydynamiclightscatteringoralmultivitaminsasamodelcase |
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Repositorios |
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1764820488528330755 |