Fc receptor-mediated immunity against Bordetella pertussis

The relevance of specific Abs for the induction of cellular effector functions against Bordetella pertussis was studied. IgG-opsonized B. pertussis was efficiently phagocytosed by human polymorphonuclear leukocytes (PMN). This process was mediated by the PMN IgG receptors, FcγRIIa (CD32) and FcγRIII...

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Autores principales:	Rodríguez, María Eugenia, Hellwig, S. M. M., Hozbor, Daniela Flavia, Leusen, J., Pol, W. L. van der, Winkel, J. G. J. van de
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2001
Materias:	Ciencias Exactas Bordetella pertussis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/84228
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-84228
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Bordetella pertussis
spellingShingle	Ciencias Exactas Bordetella pertussis Rodríguez, María Eugenia Hellwig, S. M. M. Hozbor, Daniela Flavia Leusen, J. Pol, W. L. van der Winkel, J. G. J. van de Fc receptor-mediated immunity against Bordetella pertussis
topic_facet	Ciencias Exactas Bordetella pertussis
description	The relevance of specific Abs for the induction of cellular effector functions against Bordetella pertussis was studied. IgG-opsonized B. pertussis was efficiently phagocytosed by human polymorphonuclear leukocytes (PMN). This process was mediated by the PMN IgG receptors, FcγRIIa (CD32) and FcγRIIIb (CD16), working synergistically. Furthermore, these FcγR triggered efficient PMN respiratory burst activity and mediated transfer of B. pertussis to lysosomal compartments, ultimately resulting in reduced bacterial viability. Bacteria opsonized with IgA triggered similar PMN activation via FcαR (CD89). Simultaneous engagement of FcαRI and FcγR by B. pertussis resulted in increased phagocytosis rates, compared with responses induced by either isotype alone. These data provide new insights into host immune mechanisms against B. pertussis and document a crucial role for Ig-FcR interactions in immunity to this human pathogen.
format	Articulo Articulo
author	Rodríguez, María Eugenia Hellwig, S. M. M. Hozbor, Daniela Flavia Leusen, J. Pol, W. L. van der Winkel, J. G. J. van de
author_facet	Rodríguez, María Eugenia Hellwig, S. M. M. Hozbor, Daniela Flavia Leusen, J. Pol, W. L. van der Winkel, J. G. J. van de
author_sort	Rodríguez, María Eugenia
title	Fc receptor-mediated immunity against Bordetella pertussis
title_short	Fc receptor-mediated immunity against Bordetella pertussis
title_full	Fc receptor-mediated immunity against Bordetella pertussis
title_fullStr	Fc receptor-mediated immunity against Bordetella pertussis
title_full_unstemmed	Fc receptor-mediated immunity against Bordetella pertussis
title_sort	fc receptor-mediated immunity against bordetella pertussis
publishDate	2001
url	http://sedici.unlp.edu.ar/handle/10915/84228
work_keys_str_mv	AT rodriguezmariaeugenia fcreceptormediatedimmunityagainstbordetellapertussis AT hellwigsmm fcreceptormediatedimmunityagainstbordetellapertussis AT hozbordanielaflavia fcreceptormediatedimmunityagainstbordetellapertussis AT leusenj fcreceptormediatedimmunityagainstbordetellapertussis AT polwlvander fcreceptormediatedimmunityagainstbordetellapertussis AT winkeljgjvande fcreceptormediatedimmunityagainstbordetellapertussis
bdutipo_str	Repositorios
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Fc receptor-mediated immunity against Bordetella pertussis

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