Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates

This article investigates enhancement of the dissolution profile of gliclazide, an antidiabetic drug, using the combination of solid dispersions and melt adsorption techniques. Poloxamer and PEG 6000 were utilized as hydrophilic carriers for solid dispersions preparation and lactose selected on the...

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Detalles Bibliográficos
Autores principales: Singh, Narender, Arora, Ashish, Kaushik, Deepak
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Disolución
Gliclazida
Adsorción
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8416
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_2_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8416
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Disolución
Gliclazida
Adsorción
spellingShingle Farmacia
Disolución
Gliclazida
Adsorción
Singh, Narender
Arora, Ashish
Kaushik, Deepak
Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
topic_facet Farmacia
Disolución
Gliclazida
Adsorción
description This article investigates enhancement of the dissolution profile of gliclazide, an antidiabetic drug, using the combination of solid dispersions and melt adsorption techniques. Poloxamer and PEG 6000 were utilized as hydrophilic carriers for solid dispersions preparation and lactose selected on the basis of preliminary studies was utilized as an adsorbent for the preparation of solid dispersion adsorbates. The techniques of FTIR spectroscopy, differential scanning calorimetry (DSC), and X-ray diffractometry (XRD) were performed to characterize the solid dispersions and to identify the physicochemical interaction between drug and carriers. Dissolution rate of gliclazide was higher in case of solid dispersion adsorbates as compared to solid dispersion alone and one of the marketed products. Thus the solid dispersion adsorbates can be successfully used for improvement of dissolution rate of gliclazide.
format Articulo
Comunicacion
author Singh, Narender
Arora, Ashish
Kaushik, Deepak
author_facet Singh, Narender
Arora, Ashish
Kaushik, Deepak
author_sort Singh, Narender
title Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
title_short Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
title_full Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
title_fullStr Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
title_full_unstemmed Enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
title_sort enhancement of dissolution profile of gliclazide by solid dispersion adsorbates
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8416
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_2_1.pdf
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AT aroraashish enhancementofdissolutionprofileofgliclazidebysoliddispersionadsorbates
AT kaushikdeepak enhancementofdissolutionprofileofgliclazidebysoliddispersionadsorbates
bdutipo_str Repositorios
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