Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats

Chrysanthemum is a traditional Chinese medicine used in China to treated inflammatory disease. The total flavonoids of Chrysanthemum indicum (TFC) were extracted from the dried bud of C. indicum. Our previous study had demonstrated TFC was a new class of effective anti- inflammation, analgesia and i...

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Autores principales: Hu, Rong, Jiang, Hui, Zhang, Lei, Cheng, Wen-Ming, Li, Jun, Chen, Xiao-Yu
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Flavonoides
Artritis
Inflamación
Chrysanthemum
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8412
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_24.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8412
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Flavonoides
Artritis
Inflamación
Chrysanthemum
spellingShingle Farmacia
Flavonoides
Artritis
Inflamación
Chrysanthemum
Hu, Rong
Jiang, Hui
Zhang, Lei
Cheng, Wen-Ming
Li, Jun
Chen, Xiao-Yu
Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
topic_facet Farmacia
Flavonoides
Artritis
Inflamación
Chrysanthemum
description Chrysanthemum is a traditional Chinese medicine used in China to treated inflammatory disease. The total flavonoids of Chrysanthemum indicum (TFC) were extracted from the dried bud of C. indicum. Our previous study had demonstrated TFC was a new class of effective anti- inflammation, analgesia and immunoloregulation agents. In this study, we established an adjuvant arthritis (AA) model by injection of Freund’s Complete Adjuvant (FCA) to investigate the effect of TFC on chronic autoimmune disease. Secondary paw swelling of AA rats was measured with volume meter and polyarthritis index was scored. IL-1β and TNF-α production in synoviocytes were determined by radioimmunoassay. RT-PCR observed mRNA expressions of IL-1β and TNF-α in the synovial membrane. The morphological alteration of synoviocytes organell was followed by transmission electron microscopy.
format Articulo
Articulo
author Hu, Rong
Jiang, Hui
Zhang, Lei
Cheng, Wen-Ming
Li, Jun
Chen, Xiao-Yu
author_facet Hu, Rong
Jiang, Hui
Zhang, Lei
Cheng, Wen-Ming
Li, Jun
Chen, Xiao-Yu
author_sort Hu, Rong
title Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
title_short Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
title_full Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
title_fullStr Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
title_full_unstemmed Effect of total flavonoids from Chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
title_sort effect of total flavonoids from chrysanthemum indicum on ultrastructure and secretory function of synoviocytes in adjuvant arthritis rats
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8412
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_24.pdf
work_keys_str_mv AT hurong effectoftotalflavonoidsfromchrysanthemumindicumonultrastructureandsecretoryfunctionofsynoviocytesinadjuvantarthritisrats
AT jianghui effectoftotalflavonoidsfromchrysanthemumindicumonultrastructureandsecretoryfunctionofsynoviocytesinadjuvantarthritisrats
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bdutipo_str Repositorios
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