New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
A simple, economic and time-efficient, isocratic reverse-phase ultra performance liquid chromatographic (RP-UPLC) method has been developed to analyze aripiprazole in tablets. Successful chromatographic elution and quantification of the drug was achieved on a Waters Symmetry C18, 100 mm x 4.6mm, 3.5...
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Autores principales: | , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2011
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8410 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_22.pdf |
Aporte de: |
id |
I19-R120-10915-8410 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Estudios de Validación Agentes Antipsicóticos Cromatografía de Fase Inversa Cromatografía Liquida |
spellingShingle |
Farmacia Estudios de Validación Agentes Antipsicóticos Cromatografía de Fase Inversa Cromatografía Liquida Negi, Bhawana Bansal, Ruchi Singh, Dhirendra P. Singh, Lokesh K. New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets |
topic_facet |
Farmacia Estudios de Validación Agentes Antipsicóticos Cromatografía de Fase Inversa Cromatografía Liquida |
description |
A simple, economic and time-efficient, isocratic reverse-phase ultra performance liquid chromatographic (RP-UPLC) method has been developed to analyze aripiprazole in tablets. Successful chromatographic elution and quantification of the drug was achieved on a Waters Symmetry C18, 100 mm x 4.6mm, 3.5 μm column, UV detection at 220 nm with a isocratic mobile phase comprising a mixture of component A (pH 2.5, phosphate buffer) and component B (methanol and acetonitrile (1:1, v/v) in the ratio of 45:55 (v/v). The flow rate was 1.0 mL/min. The method was validated for specificity, precision, linearity, accuracy, range, stability in analytical solution, robustness and system suitability. The linearity concentration range was 5.4-67.8 μg/mL with the correlation coefficient of 0.9997. Total elution time was about 6 min which allowed quantification of more than 100 samples per day. |
format |
Articulo Articulo |
author |
Negi, Bhawana Bansal, Ruchi Singh, Dhirendra P. Singh, Lokesh K. |
author_facet |
Negi, Bhawana Bansal, Ruchi Singh, Dhirendra P. Singh, Lokesh K. |
author_sort |
Negi, Bhawana |
title |
New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets |
title_short |
New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets |
title_full |
New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets |
title_fullStr |
New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets |
title_full_unstemmed |
New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets |
title_sort |
new validated rp-uplc method for determination of aripiprazole assay in aripiprazole tablets |
publishDate |
2011 |
url |
http://sedici.unlp.edu.ar/handle/10915/8410 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_22.pdf |
work_keys_str_mv |
AT negibhawana newvalidatedrpuplcmethodfordeterminationofaripiprazoleassayinaripiprazoletablets AT bansalruchi newvalidatedrpuplcmethodfordeterminationofaripiprazoleassayinaripiprazoletablets AT singhdhirendrap newvalidatedrpuplcmethodfordeterminationofaripiprazoleassayinaripiprazoletablets AT singhlokeshk newvalidatedrpuplcmethodfordeterminationofaripiprazoleassayinaripiprazoletablets |
bdutipo_str |
Repositorios |
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