Development and characterization of ternary solid dispersion systems of olmesartan medoxomil
The ternary solid dispersion systems of poorly water soluble olmesartan medoxomil (OLM) were prepared by conventional kneading method in order to improve its physicochemical performance. A 3<sup>2</sup> full factorial design approach was employed to optimize influence of concentration of...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8409 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_21.pdf |
| Aporte de: |
| id |
I19-R120-10915-8409 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia kneading; ternary systems; olmesartan medoxomil Análisis Factorial Cinética |
| spellingShingle |
Farmacia kneading; ternary systems; olmesartan medoxomil Análisis Factorial Cinética Rao, J. Venkateswara Pore, Yogesh V. Shinde, Vikram R. Development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| topic_facet |
Farmacia kneading; ternary systems; olmesartan medoxomil Análisis Factorial Cinética |
| description |
The ternary solid dispersion systems of poorly water soluble olmesartan medoxomil (OLM) were prepared by conventional kneading method in order to improve its physicochemical performance. A 3<sup>2</sup> full factorial design approach was employed to optimize influence of concentration of polyvinylpyrrolidone K30 (PVP) and poloxamer 407 (PLX) on physicochemical characteristics of these dispersions. All formulations were characterized by XRPD, DSC and dissolution studies. Physical studies revealed complete loss of crystallinity and formation of uniform molecular dispersion of OLM in its ternary systems. All dispersion systems showed significant improvement in dissolution profile in comparison to pure drug alone (p < 0.001). The optimized formulation provided superior solubility and dissolution behaviour (F1; DP<sub>2</sub> : 68.43 ± 2.8 %) of OLM suggesting optimum ratio of carrier system. The kinetic study of dissolution displayed to follow the Korsmeyer-Peppas model (r<sup>2</sup> = 0.9835). |
| format |
Articulo Articulo |
| author |
Rao, J. Venkateswara Pore, Yogesh V. Shinde, Vikram R. |
| author_facet |
Rao, J. Venkateswara Pore, Yogesh V. Shinde, Vikram R. |
| author_sort |
Rao, J. Venkateswara |
| title |
Development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| title_short |
Development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| title_full |
Development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| title_fullStr |
Development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| title_full_unstemmed |
Development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| title_sort |
development and characterization of ternary solid dispersion systems of olmesartan medoxomil |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8409 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_21.pdf |
| work_keys_str_mv |
AT raojvenkateswara developmentandcharacterizationofternarysoliddispersionsystemsofolmesartanmedoxomil AT poreyogeshv developmentandcharacterizationofternarysoliddispersionsystemsofolmesartanmedoxomil AT shindevikramr developmentandcharacterizationofternarysoliddispersionsystemsofolmesartanmedoxomil |
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Repositorios |
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1764820488365801472 |