Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates

The objective of the present investigation was to investigate the effects of selected drugs (captopril and celecoxib) properties on different parameters drug entrapment, in vitro drug release, release pattern, in vitro drug permeation and buoyancy in the formulation of Eudragit S100 non effervescent...

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Detalles Bibliográficos
Autores principales: Harikumar, S. L., Singh, Satish
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Partículas
Captopril
Agentes Antiinflamatorios no Esteroides
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8408
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_20.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8408
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Partículas
Captopril
Agentes Antiinflamatorios no Esteroides
spellingShingle Farmacia
Partículas
Captopril
Agentes Antiinflamatorios no Esteroides
Harikumar, S. L.
Singh, Satish
Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
topic_facet Farmacia
Partículas
Captopril
Agentes Antiinflamatorios no Esteroides
description The objective of the present investigation was to investigate the effects of selected drugs (captopril and celecoxib) properties on different parameters drug entrapment, in vitro drug release, release pattern, in vitro drug permeation and buoyancy in the formulation of Eudragit S100 non effervescent floating microparticulates. Microparticulates were in size ranges 268.36-352.27 μm (captopril) and 271.36- 365.54 μm (celecoxib). Encapsulation efficiency of celecoxib was good as compare to captopril. In vitro permeation studies showed in range (ES6) 74.83 μg – (ES1) 79.84 μg (celecoxib), (EU6) 57.01 μg - (EU1) 67.38 μg (captopril). In vitro release followed Non-Fickian diffusion mechanism while in vitro permeation kinetics revealed the super case II transport mechanism. Taken together, water insoluble (celecoxib) drug showed suitable combination with Eudragit S100. This study concluded that the effect of various parameter on the characteristics of Eudragit gastroretentive drug delivery system by non effervescent technique using celecoxib and captopril having different physicochemical characterization.
format Articulo
Articulo
author Harikumar, S. L.
Singh, Satish
author_facet Harikumar, S. L.
Singh, Satish
author_sort Harikumar, S. L.
title Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
title_short Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
title_full Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
title_fullStr Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
title_full_unstemmed Effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
title_sort effect of drug properties on formulation properties of eudragit non effervescent floating microparticulates
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8408
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_20.pdf
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