Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors
We describe a syndrome of primary microcephaly with simplified gyral pattern in combination with severe infantile epileptic encephalopathy and early-onset permanent diabetes in two unrelated consanguineous families with at least three affected children. Linkage analysis revealed a region on chromoso...
| Autores principales: | , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/83943 |
| Aporte de: |
| id |
I19-R120-10915-83943 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas microcephaly Epilepsy Infantile Diabetes |
| spellingShingle |
Ciencias Médicas microcephaly Epilepsy Infantile Diabetes Poulton, Cathryn J. Schot, Rachel Kia, Sima Kheradmand Jones Bernal, Marta Celina Verheijen, Frans W. Venselaar, Hanka Y. de Wit, Marie Claire Graaff, Esther de Bertoli Avella, Aida M. Mancini, Grazia M. S. Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| topic_facet |
Ciencias Médicas microcephaly Epilepsy Infantile Diabetes |
| description |
We describe a syndrome of primary microcephaly with simplified gyral pattern in combination with severe infantile epileptic encephalopathy and early-onset permanent diabetes in two unrelated consanguineous families with at least three affected children. Linkage analysis revealed a region on chromosome 18 with a significant LOD score of 4.3. In this area, two homozygous nonconserved missense mutations in immediate early response 3 interacting protein 1 (<i>IER3IP1</i>) were found in patients from both families. <i>IER3IP1</i> is highly expressed in the fetal brain cortex and fetal pancreas and is thought to be involved in endoplasmic reticulum stress response. We reported one of these families previously in a paper on Wolcott-Rallison syndrome (WRS). WRS is characterized by increased apoptotic cell death as part of an uncontrolled unfolded protein response. Increased apoptosis has been shown to be a cause of microcephaly in animal models. An autopsy specimen from one patient showed increased apoptosis in the cerebral cortex and pancreas beta cells, implicating premature cell death as the pathogenetic mechanism. Both patient fibroblasts and control fibroblasts treated with siRNA specific for <i>IER3IP1</i> showed an increased susceptibility to apoptotic cell death under stress conditions in comparison to controls. This directly implicates <i>IER3IP1</i> in the regulation of cell survival. Identification of <i>IER3IP1</i> mutations sheds light on the mechanisms of brain development and on the pathogenesis of infantile epilepsy and early-onset permanent diabetes. |
| format |
Articulo Articulo |
| author |
Poulton, Cathryn J. Schot, Rachel Kia, Sima Kheradmand Jones Bernal, Marta Celina Verheijen, Frans W. Venselaar, Hanka Y. de Wit, Marie Claire Graaff, Esther de Bertoli Avella, Aida M. Mancini, Grazia M. S. |
| author_facet |
Poulton, Cathryn J. Schot, Rachel Kia, Sima Kheradmand Jones Bernal, Marta Celina Verheijen, Frans W. Venselaar, Hanka Y. de Wit, Marie Claire Graaff, Esther de Bertoli Avella, Aida M. Mancini, Grazia M. S. |
| author_sort |
Poulton, Cathryn J. |
| title |
Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| title_short |
Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| title_full |
Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| title_fullStr |
Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| title_full_unstemmed |
Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| title_sort |
microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/83943 |
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