Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres

Microspheres were prepared using the emulsion/solvent evaporation method with the aim of obtaining diclofenac sodium (DFS) prolonged release dosage forms. The effects of the drug:polymer ratio and addition of Pluronic F68® to the formulations on drug content, particle size and DFS release rate were...

Descripción completa

Detalles Bibliográficos
Autores principales: Medeiros, Daniela C. de, Soldi, Valdir, Poli, Anicleto, Lemos Senna, Elenara
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Microesferas
Diclofenaco
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8376
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_20.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8376
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Microesferas
Diclofenaco
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
Microesferas
Diclofenaco
Sistemas de Liberación de Medicamentos
Medeiros, Daniela C. de
Soldi, Valdir
Poli, Anicleto
Lemos Senna, Elenara
Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
topic_facet Farmacia
Microesferas
Diclofenaco
Sistemas de Liberación de Medicamentos
description Microspheres were prepared using the emulsion/solvent evaporation method with the aim of obtaining diclofenac sodium (DFS) prolonged release dosage forms. The effects of the drug:polymer ratio and addition of Pluronic F68® to the formulations on drug content, particle size and DFS release rate were evaluated using a 22 factorial design. The DFS encapsulation efficiency (%) and the drug content varied from 40 to 70 % and from 4.5 to 13 mg/100 mg, respectively. The mean particle diameter varied from 720 to 850 μm. The addition of Pluronic F68® to the formulations led to an increase in the roughness of the surface. The differential scanning calorimetry (DSC) and infrared spectroscopy (FTIR) studies indicated the presence of Pluronic F68® in the particles. The statistical analysis revealed that the drug content and the release rate of DFS were significantly increased when 1:4 drug:polymer ratio and Pluronic F68® was used to prepare the microspheres.
format Articulo
Articulo
author Medeiros, Daniela C. de
Soldi, Valdir
Poli, Anicleto
Lemos Senna, Elenara
author_facet Medeiros, Daniela C. de
Soldi, Valdir
Poli, Anicleto
Lemos Senna, Elenara
author_sort Medeiros, Daniela C. de
title Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
title_short Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
title_full Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
title_fullStr Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
title_full_unstemmed Potential use of cellulose acetate butyrate and pluronic F68® blends in the modulation of the diclofenac sodium release from microspheres
title_sort potential use of cellulose acetate butyrate and pluronic f68® blends in the modulation of the diclofenac sodium release from microspheres
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8376
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_20.pdf
work_keys_str_mv AT medeirosdanielacde potentialuseofcelluloseacetatebutyrateandpluronicf68blendsinthemodulationofthediclofenacsodiumreleasefrommicrospheres
AT soldivaldir potentialuseofcelluloseacetatebutyrateandpluronicf68blendsinthemodulationofthediclofenacsodiumreleasefrommicrospheres
AT polianicleto potentialuseofcelluloseacetatebutyrateandpluronicf68blendsinthemodulationofthediclofenacsodiumreleasefrommicrospheres
AT lemossennaelenara potentialuseofcelluloseacetatebutyrateandpluronicf68blendsinthemodulationofthediclofenacsodiumreleasefrommicrospheres
bdutipo_str Repositorios
_version_ 1764820488965586945

Ejemplares similares