Taste masked orodispersible tablet of atomoxetine hydrochloride

In the present work, orodispersible tablets of atomoxetine HCl were designed by preparing tasteless complexes of atomoxetine HCl with weak cation ion exchange resins (Kyron T 134). The ion exchange complex were prepared by the batch process using activated Kyron T 134 with a drug: resin ratios 1:1,...

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Detalles Bibliográficos
Autores principales:	Huda, Inderjeet S.G., Toshniwal, Sanjay S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia atomoxetine HCl; Kyron T 134; orodispersible tablet Comprimidos Resinas de Intercambio Iónico
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8375 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_19.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8375
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia atomoxetine HCl; Kyron T 134; orodispersible tablet Comprimidos Resinas de Intercambio Iónico
spellingShingle	Farmacia atomoxetine HCl; Kyron T 134; orodispersible tablet Comprimidos Resinas de Intercambio Iónico Huda, Inderjeet S.G. Toshniwal, Sanjay S. Taste masked orodispersible tablet of atomoxetine hydrochloride
topic_facet	Farmacia atomoxetine HCl; Kyron T 134; orodispersible tablet Comprimidos Resinas de Intercambio Iónico
description	In the present work, orodispersible tablets of atomoxetine HCl were designed by preparing tasteless complexes of atomoxetine HCl with weak cation ion exchange resins (Kyron T 134). The ion exchange complex were prepared by the batch process using activated Kyron T 134 with a drug: resin ratios 1:1, 1:2, 1:3 and 1:4 (% w/w). IR analysis, assay content and decomplexation studies confirmed complex formation. It was found that maximum complexation of drug with resin was noted between pH range 5-7, while activation of ion exchange resin affects the percent drug loading. Drug release from drug: resin complex in salivary pH was insufficient to impart bitter taste. A study on super-disintegrants along with directly compressible diluents is studied and its effect on disintegration time and enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity and in vitro dispersion time. Based on in vitro disintegration time (approximately 30 s), formulations were tested for in vitro drug release pattern in 0.1N HCl.
format	Articulo Articulo
author	Huda, Inderjeet S.G. Toshniwal, Sanjay S.
author_facet	Huda, Inderjeet S.G. Toshniwal, Sanjay S.
author_sort	Huda, Inderjeet S.G.
title	Taste masked orodispersible tablet of atomoxetine hydrochloride
title_short	Taste masked orodispersible tablet of atomoxetine hydrochloride
title_full	Taste masked orodispersible tablet of atomoxetine hydrochloride
title_fullStr	Taste masked orodispersible tablet of atomoxetine hydrochloride
title_full_unstemmed	Taste masked orodispersible tablet of atomoxetine hydrochloride
title_sort	taste masked orodispersible tablet of atomoxetine hydrochloride
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8375 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_19.pdf
work_keys_str_mv	AT hudainderjeetsg tastemaskedorodispersibletabletofatomoxetinehydrochloride AT toshniwalsanjays tastemaskedorodispersibletabletofatomoxetinehydrochloride
bdutipo_str	Repositorios
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Taste masked orodispersible tablet of atomoxetine hydrochloride

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